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1. (Article ID: 4748)
Arbatsky NP, Shneider MM, Kenyon JJ, Shashkov AS, Popova AV, Miroshnikov KA, Volozhantsev NV, Knirel YA
Structure of the neutral capsular polysaccharide of Acinetobacter baumannii NIPH146 that carries the KL37 capsule gene cluster
Carbohydrate Research 413 (2015)
12-15
Capsular polysaccharide (CPS) was isolated from Acinetobacter baumannii NIPH146, and the following structure of branched pentasaccharide repeating unit was established by sugar analyses along with 1D and 2D NMR spectroscopy: In comparison to most other known capsular polysaccharides of A. baumannii, the CPS studied is neutral and lacks any specific monosaccharide component. The synthesis, assembly and export of this structure could be attributed to genes in a novel capsule biosynthesis gene cluster, designated KL37, which was found in the NIPH146 genome. The CPS of A. baumannii NIPH146 shares the α-d-Galp-(1→6)-β-d-Glcp-(1→3)-d-GalpNAc-(1→ trisaccharide fragment with the CPS units of several A. baumannii strains, including ATCC 17978 and LUH 5537 that carry the KL3 and KL22 gene clusters, respectively. KL37 contains two genes for glycosyltransferases that are related to two glycosyltransferase genes present in both KL3 and KL22, and the encoded proteins could be tentatively assigned to linkages between sugars in the CPS repeat.
Acinetobacter baumannii, capsular polysaccharide structure, glycosyltransferase, K locus, KL37 gene cluster
NCBI PubMed ID: 26057991Publication DOI: 10.1016/j.carres.2015.05.003Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: Y.A. Knirel
gmail.com>
Institutions: N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia, State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, Russia, M. M. Shemyakin and Y. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia, School of Molecular Bioscience, The University of Sydney, Sydney, Australia, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia
Methods: 13C NMR, 1H NMR, NMR-2D, sugar analysis, acid hydrolysis, GLC, NMR-1D, bioinformatic analysis
The publication contains the following compound(s):
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2. (Article ID: 4819)
Giguere D
Surface polysaccharides from Acinetobacter baumannii: Structures and syntheses
Carbohydrate Research 418 (2015)
29-43
The emergence of multidrug-resistance Acinetobacter baumannii requires novel approaches for prevention, treatment and diagnosis. The structures of surface polysaccharides from A. baumannii are valuable tools to understand pathogenesis, virulence and immunogenicity. The synthesis of bacterial mono- or polysaccharides may result in novel probes to become important therapeutic options in the fight against A. baumannii. This report exemplifies the relevance of glycochemistry for the development of new antibiotics.
lipopolysaccharides, capsular polysaccharides, Acinetobacter, Acinetobacter baumannii, polysaccharide synthesis, surface polysaccharides
NCBI PubMed ID: 26531136Publication DOI: 10.1016/j.carres.2015.10.001Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: denis.giguere
chm.ulaval.ca
Institutions: Département de Chimie, Université Laval, Québec City, Québec, Canada G1V 0A6
The publication contains the following compound(s):
- Compound ID: 12079
Structure type: homopolymer
; n=9
Aglycon: 3-(4-(acetylthio)butyrylamino)propyl or spacer + carrier protein (Tetanus Toxoid)
Trivial name: PNAG
Reference(s) to other database(s): GTC:G11006VI
- Compound ID: 327
Structure type: polymer chemical repeating unit
Compound class: CPS, O-polysaccharide, O-antigen
Reference(s) to other database(s): GTC:G70774JU, GlycomeDB:
25556
- Compound ID: 328
Structure type: polymer chemical repeating unit
Compound class: O-polysaccharide, O-antigen, LPS, cell wall polysaccharide
Reference(s) to other database(s): GTC:G52429QS, GlycomeDB:
6694
- Compound ID: 728
|
a-L-FucpNAc-(1-4)-+
|
-3)-a-D-GalpNAcA-(1-3)-a-L-FucpNAc-(1-3)-b-D-GlcpNAc-(1- |
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Structure type: polymer chemical repeating unit
Compound class: CPS, O-polysaccharide, O-antigen
Reference(s) to other database(s): GTC:G73635WZ, GlycomeDB:
25208
- Compound ID: 12077
|
a-Kdop-(2-4)-+
|
b-D-GlcpN-(1-7)-+ |
| |
a-D-GalpN(%)Ac-(1-4)-+ | |
| | |
a-D-Glcp-(1-2)-b-D-Glcp-(1-4)-b-D-Glcp-(1-4)-b-D-Glcp-(1-3)-a-D-GlcpNAcA-(1-4)-a-Kdop-(2-5)-a-Kdop-(2--/lipid A/ |
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Structure type: oligomer
Aglycon: lipid A
Compound class: core oligosaccharide
Reference(s) to other database(s): GTC:G80033MB
- Compound ID: 12078
|
a-Kdop-(2-4)-+
|
b-D-GlcpN-(1-7)-+ |
| |
a-D-GalpN(%)Ac-(1-4)-a-D-GlcpNAcA-(1-4)-a-Kdop-(2-5)-a-Kdop-(2--/lipid A/ |
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Structure type: oligomer
Aglycon: lipid A
Compound class: core oligosaccharide
Reference(s) to other database(s): GTC:G20251VZ
- Compound ID: 12072
|
/Variants 0/-+
|
-4)-a-D-GlcpNAc6(50%)Ac-(1-4)-a-D-GalpNAcA-(1-3)-b-D-QuipNAc4N-(1-
/Variants 0/ is:
66%Ac-4)-
OR (exclusively)
33%R-3HOBut-(1-4)- |
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Structure type: polymer chemical repeating unit
Compound class: O-polysaccharide
- Compound ID: 2076
|
b-D-ManpNAc-(1-4)-a-D-Galp-(1-4)-+
|
-3)-b-D-GalpNAc-(1-3)-b-D-Galp-(1- |
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Structure type: polymer chemical repeating unit
Compound class: CPS, O-polysaccharide, O-antigen
Reference(s) to other database(s): GTC:G40148IO, GlycomeDB:
25205
- Compound ID: 12080
Structure type: oligomer
Trivial name: repeating unit of the O-polysaccharide
Reference(s) to other database(s): GTC:G50329IW
- Compound ID: 2077
|
b-D-Glcp-(1-6)-+
|
-4)-b-D-GalpNAc-(1-3)-a-D-Galp-(1-6)-b-D-Galp-(1-3)-a-D-GalpNAc-(1- |
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Structure type: polymer chemical repeating unit
Compound class: CPS, O-polysaccharide, O-antigen
Reference(s) to other database(s): GTC:G69238MT, GlycomeDB:
25206
- Compound ID: 2078
|
b-D-Glcp-(1-3)-+
|
-6)-a-D-GlcpNAc-(1-4)-a-D-GalpNAc-(1-3)-a-D-GlcpNAc-(1- |
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Structure type: polymer chemical repeating unit
Trivial name: surface polysaccharide
Compound class: CPS, O-polysaccharide, O-antigen
Reference(s) to other database(s): GTC:G53088UD, GlycomeDB:
25207
- Compound ID: 2085
|
/Variants 0/-+
|
-6)-a-D-GlcpNAc-(1-3)-a-L-FucpNAc-(1-3)-a-D-GlcpNAc-(1-4)-b-Legp7Ac-(2-
/Variants 0/ is:
50%S-3HOBut-(1-5)-
OR (exclusively)
50%Ac-5)- |
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Structure type: polymer chemical repeating unit
Compound class: O-polysaccharide, O-antigen
- Compound ID: 2087
|
R-3HOBut-(1-3)-b-D-Quip3N-(1-6)-a-D-GlcpNAc-(1-4)-+
|
-3)-b-D-GlcpNAc-(1-3)-b-D-GalpNAc-(1-3)-a-D-Galp-(1- |
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Structure type: polymer chemical repeating unit
Compound class: CPS, O-polysaccharide, O-antigen
- Compound ID: 2088
|
a-D-Glcp-(1-6)-+
|
-3)-b-D-Quip4NAc-(1-3)-a-D-GalpNAc-(1-4)-a-D-GalpNAc-(1-3)-a-D-GalpNAc-(1- |
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Structure type: polymer chemical repeating unit
Trivial name: type K57 CPS
Compound class: CPS, O-polysaccharide, O-antigen
Reference(s) to other database(s): GTC:G82786KR, GlycomeDB:
25210, SpecDB: ol.9
- Compound ID: 2089
|
b-L-Rhap-(1-4)-b-D-GlcpNAc-(1-3)-+
|
-3)-a-D-GlcpNAc-(1-2)-a-L-Rhap-(1-2)-a-L-Rhap-(1-3)-a-L-Rhap-(1- |
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Structure type: polymer chemical repeating unit
Compound class: CPS, O-polysaccharide, O-antigen
Reference(s) to other database(s): GTC:G32499RM, GlycomeDB:
25211
- Compound ID: 5483
|
a-D-ManpNAc-(1-3)-+
|
-3)-a-D-GlcpNAc-(1-2)-a-L-Rhap-(1-2)-a-L-Rhap-(1-3)-a-L-Rhap-(1- |
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Structure type: polymer chemical repeating unit
Compound class: CPS, O-polysaccharide, O-antigen
Reference(s) to other database(s): GTC:G94329VK, GlycomeDB:
6779
- Compound ID: 8566
|
b-D-GlcpNAc3NAcA-(1-4)-+
|
-6)-b-D-Glcp-(1-3)-b-D-GalpNAc-(1-3)-a-D-Galp-(1-
|
b-D-GlcpNAc-(1-6)-+ |
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Structure type: polymer chemical repeating unit
Compound class: CPS, O-polysaccharide, O-antigen
Reference(s) to other database(s): GTC:G47927SM, GlycomeDB:
37288
- Compound ID: 11322
|
b-D-GlcpNAc3NAcA4Ac-(1-4)-+
|
-3)-a-D-Galp-(1-6)-b-D-Glcp-(1-3)-b-D-GalpNAc-(1-
|
b-D-GlcpNAc-(1-6)-+ |
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Structure type: polymer chemical repeating unit
Trivial name: O-glycan
Compound class: CPS
Reference(s) to other database(s): GTC:G64997NS
- Compound ID: 12073
|
/Variants 0/-+
|
-4)-a-D-GlcpNAc6(50%)Ac-(1-4)-a-L-GalpNAcA-(1-3)-b-D-QuipNAc4N-(1-
/Variants 0/ is:
66%Ac-4)-
OR (exclusively)
33%R-3HOBut-(1-4)- |
Show graphically |
Structure type: polymer chemical repeating unit
Compound class: CPS
- Compound ID: 10877
|
a-Kdop-(2-4)-+
|
b-D-GlcpN-(1-7)-+ |
| |
a-D-GalpN-(1-4)-+ | |
| | |
a-D-Glcp-(1-2)-b-D-Glcp-(1-4)-b-D-Glcp-(1-4)-b-D-Glcp-(1-3)-a-D-GlcpNAcA-(1-4)-a-Kdop-(2-5)-a-Kdop-(2--/lipid A/ |
Show graphically |
Structure type: oligomer
Aglycon: lipid A
Compound class: core oligosaccharide, LOS
Reference(s) to other database(s): GTC:G87252TX
- Compound ID: 12076
|
a-Kdop-(2-4)-+
|
a-D-GlcpNAc-(1-4)-b-D-GlcpNA-(1-4)-+ |
| |
?%a-L-Rhap-(1-3)-?%a-L-Rhap-(1-3)-a-L-Rhap-(1-3)-a-L-Rhap-(1-8)-a-Kdop-(2-5)-a-Kdop-(2-5)-a-Kdop-(2--/lipid A/ |
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Structure type: oligomer
Aglycon: lipid A
Compound class: core oligosaccharide
Reference(s) to other database(s): GTC:G08271SD
- Compound ID: 11621
|
a-Psep5Ac7Ac-(2-6)-b-D-Glcp-(1-6)-+
|
-3)-b-D-Galp-(1-3)-b-D-GalpNAc-(1- |
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Structure type: polymer chemical repeating unit
Compound class: CPS, polysaccharide
Reference(s) to other database(s): GTC:G97931NE, GenDB:JX976549.1
- Compound ID: 11852
Structure type: polymer chemical repeating unit
Compound class: CPS, cell wall polysaccharide
Reference(s) to other database(s): GTC:G73006WP
- Compound ID: 11899
|
b-D-Glcp-(1-6)-+
|
-4)-b-D-GalpNAc-(1-4)-a-D-Galp-(1-6)-b-D-Glcp-(1-3)-b-D-GalpNAc-(1- |
Show graphically |
Structure type: polymer chemical repeating unit
Compound class: CPS
Reference(s) to other database(s): GTC:G71656OE
- Compound ID: 12074
|
-4)-a-Psep5Ac7Ac-(2-6)-b-D-Galp-(1-6)-b-D-Galp-(1-3)-a-D-GalpNAc-(1- |
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Structure type: polymer chemical repeating unit
Compound class: CPS
Reference(s) to other database(s): GTC:G91504ME
- Compound ID: 12026
Structure type: polymer chemical repeating unit
Compound class: CPS
Reference(s) to other database(s): GTC:G52976SY
- Compound ID: 12014
|
R-3HOBut-(1-7)-a-Psep5Ac-(2-4)-+
|
-3)-b-D-Ribp-(1-3)-b-D-GalpNAc-(1- |
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Structure type: polymer chemical repeating unit
Compound class: CPS
- Compound ID: 12013
|
/Variants 0/-+
|
-3)-b-D-ManpNAcA-(1-4)-b-D-ManpNAcA-(1-3)-a-D-QuipNAc4N-(1-
/Variants 0/ is:
71%S-3HOBut-(1-4)-
OR (exclusively)
29%Ac-4)- |
Show graphically |
Structure type: polymer chemical repeating unit
Compound class: CPS
- Compound ID: 12028
|
b-D-Glcp-(1-3)-+
|
-2)-a-D-Galp-(1-6)-a-D-Glcp-(1-4)-a-D-GalpNAc-(1-3)-b-D-GalpNAc-(1- |
Show graphically |
Structure type: polymer chemical repeating unit
Compound class: CPS
Reference(s) to other database(s): GTC:G68883RH
- Compound ID: 12029
|
b-D-Glcp-(1-3)-+
|
-3)-a-D-Glcp-(1-6)-a-D-GlcpNAc-(1-4)-a-D-Galp-(1-3)-b-D-GlcpNAc-(1- |
Show graphically |
Structure type: polymer chemical repeating unit
Compound class: CPS
Reference(s) to other database(s): GTC:G35428RP
- Compound ID: 12031
|
b-D-Glcp-(1-3)-+
|
-4)-a-D-GalpNAc6(50%)Ac-(1-4)-a-D-GalpNAc-(1-3)-a-D-GlcpNAc-(1- |
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Structure type: polymer chemical repeating unit
Compound class: CPS
Reference(s) to other database(s): GTC:G57327XB
- Compound ID: 12075
|
a-Acip5Ac7Ac-(2-6)-+
|
-3)-a-D-GalpNAc-(1-3)-a-L-FucpNAc-(1-3)-a-D-FucpNAc-(1-
Aci = 5,7-diamino-3,5,7,9-tetradeoxy-L-glycero-L-altro-non-2-ulosonic (acinetaminic) acid (5,7-di-N-acetyl-acinetaminic acid Aci5Ac7Ac) |
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Structure type: polymer chemical repeating unit
Compound class: CPS
Reference(s) to other database(s): GTC:G90675WE
- Compound ID: 1030
Structure type: homopolymer
Trivial name: poly-β-1,6-GlcNAc (PGA), biofilm, poly-b-(1-6)-N-acetyl-D-glucosamine (PNAG), poly-β-N-acetyl-glucosamine (PNAG), PNAG, poly-N-acetylglucosamine, PNAG
Compound class: CPS, EPS, O-polysaccharide, glucan, polysaccharide
Reference(s) to other database(s): GTC:G36952FI, GlycomeDB:
11210
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