Found 1 structure.
Displayed structure 1
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1. Compound ID: 4796
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a-Neup5Ac-(2-3)-+
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b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)-b-D-Galp-(1-4)-b-D-Glcp-(1--/rest of molecule/ |
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Structure type: oligomer
Aglycon: rest of molecule
Trivial name: GM1 analog
Compound class: glycolipid
Contained glycoepitopes: IEDB_130648,IEDB_130678,IEDB_130679,IEDB_130683,IEDB_134627,IEDB_136044,IEDB_136794,IEDB_137472,IEDB_137473,IEDB_141794,IEDB_142487,IEDB_142488,IEDB_146100,IEDB_146664,IEDB_147450,IEDB_147451,IEDB_149174,IEDB_150933,IEDB_190606,IEDB_547903,IEDB_983931,SB_116,SB_144,SB_164,SB_165,SB_166,SB_170,SB_171,SB_172,SB_187,SB_192,SB_195,SB_23,SB_24,SB_25,SB_37,SB_39,SB_6,SB_68,SB_7,SB_76,SB_8,SB_84,SB_88,SB_96
The structure is contained in the following publication(s):
- Article ID: 1798
Yuki N, Handa S, Taki T, Kasama T, Takahashi M, Saito K, Miyatake T "Cross-reactive antigen between nervous tissue and a bacterium elicits Guillain-Barré syndrome: Molecular mimicry between ganglioside GM1 and lipopolysaccharide from Penner's serotype 19 of Campylobacter jejuni" -
Biomedical Research (India) 13 (1992) 451-453
We investigated the lipopolysaccharide (LPS) from Penner's serotype 19 (PEN 19) of C. jejuni that had been isolated from a patient with the Guillain-Barre syndrome (GBS). The LPS was extracted from the bacterium and separated by a silica beads column chromatography. One homogeneous fraction showing reactivity with the patient's serum, rabbit anti-G(M1) antibody, and also with cholera toxin, which binds oligosaccharide of G(M1), was obtained. By gas-liquid chromatography-mass spectrometric analysis, the purified LPS was found to contain D-galactose, D-glucose, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, N-acetylneuraminic acid; 3-deoxy-2-octulosonic acid, heptose and fatty acids (3-hydroxy-myristic acid and palmitic acid). The result indicates that sugar components of the G(M1)-oligosaccharide are present in the purified LPS. Chemical analysis and immunological binding experiment show that the LPS from C. jejuni (PEN 19) has the oligosaccharide structure in common with G(M1) ganglioside. These results suggest that some GBS patients associated with anti-G(M1), antibody are caused by an autoimmune mechanism after infection by C.jejuni (PEN 19) which has the G(M1)-oligosaccharide structure.
Publication DOI: 10.2220/biomedres.13.451Journal NLM ID: 9102548Publisher: Aligarh, India: Scientific Publishers of India
Institutions: Department of Neurology, Faculty of Medicine, Tokyo Medical and Dental University, Japan
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