CSDB: Search results

Taxonomic group: protista / Euglenozoa (Phylum: Euglenozoa)
Host organism: (mammal)
Organ / tissue: Life stage: procyclic form
Associated disease: infection due to Trypanosoma brucei [ICD11: XN0C1

]

NCBI PubMed ID: 35536961
Publication DOI: 10.1101/glycobiology.4e.43
Publisher: Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press
Editors: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Mohnen D, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger RH
Correspondence: R.D. Cummings <rcummin1

bidmc.harvard.edu>
Institutions: Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA, Department of Molecular Cell Biology & Immunology, VU University Center, Amsterdam, The Netherlands

Parasitic protozoans and helminths (worms) synthesize glycans with structures often different from those typically found in vertebrates, and are thus often antigenic. Parasites also express glycan-binding proteins (GBPs) involved in host invasion and parasitism. As part of the disease process, parasite glycans can trigger the host's innate immune system, which can lead to the induction of adaptive immune responses. This chapter discusses the major roles of glycoconjugates in parasitic infections.

Structure type: oligomer
Location inside paper: Fig. 43.2
Trivial name: procyclin glycoprotein
Compound class: GPI-anchor, GPI-anchored polypeptides
Contained glycoepitopes: IEDB_120354,IEDB_123886,IEDB_123890,IEDB_130646,IEDB_130701,IEDB_135813,IEDB_136044,IEDB_136104,IEDB_136794,IEDB_136906,IEDB_137340,IEDB_137472,IEDB_137485,IEDB_1391962,IEDB_140108,IEDB_140116,IEDB_140122,IEDB_141181,IEDB_141793,IEDB_141794,IEDB_141807,IEDB_141828,IEDB_141829,IEDB_142078,IEDB_143242,IEDB_143632,IEDB_143794,IEDB_144983,IEDB_144993,IEDB_146100,IEDB_149174,IEDB_150899,IEDB_150933,IEDB_151079,IEDB_151528,IEDB_151531,IEDB_152206,IEDB_153212,IEDB_153220,IEDB_153529,IEDB_157001,IEDB_158533,IEDB_164174,IEDB_187201,IEDB_190606,IEDB_241110,IEDB_241112,IEDB_423120,IEDB_429156,IEDB_474450,IEDB_534865,IEDB_548907,IEDB_857734,IEDB_983930,SB_115,SB_116,SB_127,SB_131,SB_136,SB_137,SB_156,SB_165,SB_166,SB_170,SB_171,SB_172,SB_173,SB_186,SB_187,SB_191,SB_195,SB_196,SB_197,SB_198,SB_29,SB_30,SB_33,SB_39,SB_44,SB_67,SB_68,SB_7,SB_72,SB_73,SB_74,SB_77,SB_84,SB_85,SB_88

Comments, role: Bookshelf ID: NBK579956, (no PDF, only Internet) review

NCBI Taxonomy refs (TaxIDs): 5691
Show glycosyltransferases

There is only one chemically distinct structure:

[2*]O[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@H](CO[C@H]4O[C@H](CO)[C@@H](O)[C@H](O[C@H]5O[C@H](CO)[C@H](O)[C@H](O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](CO[C@@H]9O[C@H](CO)[C@@H](O[C@@H]%10O[C@H](CO)[C@H](O)[C@H](O[C@]%11(C(=O)O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O%11)[C@H]%10O)[C@H](O)[C@H]9NC(C)=O)[C@H](O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7NC(C)=O)[C@H](O)[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O[C@@H]8O[C@H](CO[C@@H]9O[C@H](CO)[C@@H](O[C@@H]%10O[C@H](CO)[C@H](O)[C@H](O[C@]%11(C(=O)O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O%11)[C@H]%10O)[C@H](O)[C@H]9NC(C)=O)[C@H](O)[C@H](O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O[C@@H]%10O[C@H](CO)[C@H](O)[C@H](O[C@@H]%11O[C@H](CO)[C@@H](O)[C@H](O[C@@H]%12O[C@H](CO)[C@H](O)[C@H](O[C@]%13(C(=O)O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O%13)[C@H]%12O)[C@H]%11NC(C)=O)[C@H]%10O)[C@H]9NC(C)=O)[C@H]8O)[C@H]7NC(C)=O)[C@H]6O)[C@H]5O)[C@@H]4O[C@H]4O[C@H](COP(=O)(O)OCCN[1*]O[C@@H]5O[C@H](CO)[C@@H](O[C@@H]6O[C@H](CO)[C@@H](O[C@@H]7O[C@H](CO[C@H]8O[C@H](CO[C@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]9O)[C@@H](O)[C@H](O[C@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]9O)[C@@H]8O)[C@@H](O)[C@H](O[C@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]8O)[C@@H]7O)[C@H](O)[C@H]6NC(C)=O)[C@H](O)[C@H]5NC(C)=O)[C@@H](O)[C@H](OC5O[C@H](CO)[C@H](O)[C@H](O)[C@H]5O)[C@@H]4O)[C@@H](O)[C@H](O)[C@@H]3O)[C@H](O)[C@H]2N)[C@H]1OP(=O)(O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC

SVG MW SMILES 3D mol Ionize

R1 = protein
R2 = lXC18={?}