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Cummings RD, Van Die I
Parasitic Infections
Book: In: Essentials of Glycobiology [Internet]. 3rd edition. (2017)
|
a-D-Manp-(1-2)-+ Aep-(1-6)-+
| |
Subst-(1-2)-EtN-(1--P--6)--a-D-Manp-(1-2)-a-D-Manp-(1-6)-a-D-Manp-(1-4)-a-D-GlcpN-(1-6)-myoIno-(1--P--1)--CER
Subst = protein |
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Trypanosoma cruzi
(NCBI TaxID 5693,
species name lookup)
Taxonomic group: protista / Euglenozoa
(Phylum: Euglenozoa)
Host organism: (mammal)
Organ / tissue: Life stage: metacyclic formAssociated disease: Chagas disease [ICD11:
1F53 
, ICD11:
XN56V ];
infection due to Trypanosoma cruzi [ICD11:
XN56V ]
NCBI PubMed ID: 28876851Publication DOI: 10.1101/glycobiology.3e.043Publisher: Cold Spring Harbor (NY), Cold Spring Harbor Laboratory Press, 2015-2017
Editors: Varki A, Cummings RD, Esko JD
Correspondence: Richard D. Cummings <rcummin1
bidmc.harvard.edu>; Irma van Die <irma.van.die
gmail.com>
Institutions: Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA, Department of Molecular Cell Biology & Immunology, VU University Center, Amsterdam, The Netherlands
Parasitic protozoans and helminths (worms) synthesize glycans with structures often different from those typically found in vertebrates and are typically antigenic. Parasites also express glycan-binding proteins (GBPs) involved in host invasion and parasitism. As part of the disease process, parasite glycans can trigger the host's innate immune system, which can lead to the induction of adaptive immune responses. This chapter discusses the major roles of glycoconjugates in parasitic infections.
Structure type: oligomer
Location inside paper: Fig. 43.3, GIPL
Compound class: glycosylinositolphospholipid
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130701,IEDB_136104,IEDB_140116,IEDB_141793,IEDB_141807,IEDB_141829,IEDB_141830,IEDB_141832,IEDB_143632,IEDB_144983,IEDB_144993,IEDB_151531,IEDB_152206,IEDB_153220,IEDB_474450,IEDB_76933,IEDB_983930,SB_136,SB_191,SB_196,SB_198,SB_44,SB_67,SB_72
Comments, role: review; when life stage: epimastigotes/trypomastigotes GIPL is composed of an alkylacylphosphatidylinositol-anchored glycan.
NCBI Taxonomy refs (TaxIDs): 5693
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There is only one chemically distinct structure:
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Cummings RD, Hokke CH, Haslam SM
Parasitic Infections
Book: Essentials of Glycobiology [Internet]. 4rd edition (2022)
|
a-D-Manp-(1-2)-+ Aep-(1-6)-+
| |
Subst-(1-2)-EtN-(1--P--6)--a-D-Manp-(1-2)-a-D-Manp-(1-6)-a-D-Manp-(1-4)-a-D-GlcpN-(1-6)-myoIno-(1--P--1)--CER
Subst = protein |
Show graphically |
Trypanosoma cruzi
(NCBI TaxID 5693,
species name lookup)
Taxonomic group: protista / Euglenozoa
(Phylum: Euglenozoa)
Host organism: (mammal)
Organ / tissue: Life stage: metacyclic formAssociated disease: Chagas disease [ICD11:
1F53 , ICD11:
XN56V ];
infection due to Trypanosoma cruzi [ICD11:
XN56V ]
NCBI PubMed ID: 35536961Publication DOI: 10.1101/glycobiology.4e.43Publisher: Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press
Editors: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Mohnen D, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger RH
Correspondence: R.D. Cummings <rcummin1
bidmc.harvard.edu>
Institutions: Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA, Department of Molecular Cell Biology & Immunology, VU University Center, Amsterdam, The Netherlands
Parasitic protozoans and helminths (worms) synthesize glycans with structures often different from those typically found in vertebrates, and are thus often antigenic. Parasites also express glycan-binding proteins (GBPs) involved in host invasion and parasitism. As part of the disease process, parasite glycans can trigger the host's innate immune system, which can lead to the induction of adaptive immune responses. This chapter discusses the major roles of glycoconjugates in parasitic infections.
Structure type: oligomer
Location inside paper: Fig. 43.3, GIPL
Compound class: glycosylinositolphospholipid
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130701,IEDB_136104,IEDB_140116,IEDB_141793,IEDB_141807,IEDB_141829,IEDB_141830,IEDB_141832,IEDB_143632,IEDB_144983,IEDB_144993,IEDB_151531,IEDB_152206,IEDB_153220,IEDB_474450,IEDB_76933,IEDB_983930,SB_136,SB_191,SB_196,SB_198,SB_44,SB_67,SB_72
Comments, role: Bookshelf ID: NBK579956, (no PDF, only Internet) review
NCBI Taxonomy refs (TaxIDs): 5693
Show glycosyltransferases
There is only one chemically distinct structure:
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