Wu YN, Chen Y, Huang XS, Pan YH, Liu ZM, Yan T, Cao WH, She ZG α-Glucosidase Inhibitors: Diphenyl Ethers and Phenolic Bisabolane Sesquiterpenoids from the Mangrove Endophytic Fungus Aspergillus flavus QQSG-3 Marine Drugs16(9) (2018)
ID: 307 (1-9)
The structure was elucidated in this paper NCBI PubMed ID:30200400 Publication DOI:10.3390/md16090307 Journal NLM ID:101213729 Publisher: Basel, Switzerland: Molecular Diversity Preservation International Correspondence: Wu YN <wuyn3mail2.sysu.edu.cn>; Huang XS <huangxsh9mail.sysu.edu.cn>; Pan YH <pan16a126.com>; Chen Y <chenyan27mail2.sysu.edu.cn>; Yan T <yantaoscsio.ac.cn>; Cao WH <chromo163.com>; Liu ZM <liuzhaommail2.sysu.edu.cn>; She ZG <cesshzhgmail.sysu.edu.cn> Institutions: School of Chemistry, Sun Yat-Sen University, Guangzhou, China, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, School of Marine Sciences, Sun Yat-Sen University, Guangzhou, China, State Key Laboratory of Applied Microbiology, Southern China, Guangdong Institute of Microbiology, Guangzhou, China, CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China
Two new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3-6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the province of Guangdong, China. The structures of compounds 1-6 were determined by analyzing NMR and HRESIMS data. The absolute configurations of 5 and 6 were assigned by comparing their experimental ECD spectra with those reported for similar compounds in the literature. All isolates were evaluated for their -glucosidase inhibitory activity, of which compounds 3, 5, 10, and 11 showed strong inhibitory effects with IC50 values in the range of 1.5-4.5 M.
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mail2.sysu.edu.cn>; Huang XS <huangxsh9