Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Host organism: Dichotella gemmacea
Organ / tissue: cell wall
The structure was elucidated in this paperPublication DOI: 10.1080/14786419.2017.1342086Journal NLM ID: 101167924Publisher: Milton Park, UK : Taylor & Francis Health Sciences
Correspondence: Wang CY <changyun
ouc.edu.cn>
Institutions: Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, the Ministry of Education of China, Qingdao, China, Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding, China
A new pregnane, 3-hydroxy-7-ene-6,20-dione (1), and five known steroids (2-6), along with one known steroidal glycoside (7) were obtained from the fungus Cladosporium sp. WZ-2008-0042 cultured from a gorgonian Dichotella gemmacea collected from the South China Sea. The structure and absolute configuration of the new compound (1) were elucidated by comprehensive spectroscopic data and X-ray diffraction data. The compound has a rare configuration of 3-OH that is different from most of pregnanes. All of the isolated compounds were evaluated for their antiviral activities against respiratory syncytial virus (RSV). Among them, 1 exhibited potential antiviral activity with the IC50 value of 0.12mM.
structure elucidation, Cladosporium sp, gorgonian Dichotella gemmacea, 3-OH pregnane, antiviral activity
Structure type: monomer ; 949
Location inside paper: fig. 1 (compound 7)
Compound class: steroid glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, IR, inhibition studies, TLC, HPLC, extraction, column chromatography, antibacterial assay, optical rotation measurements, HRMSISMS
NCBI Taxonomy refs (TaxIDs): 5498
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error