Found 1 publication.
Displayed publication 1
Expand all publications
Collapse all publications
Show all as text (SweetDB notation)
Show all graphically (SNFG notation)
1. (Article ID: 4951)
Kenyon JJ, Speciale I, Hall RM, De Castro C
Structure of repeating unit of the capsular polysaccharide from Acinetobacter baumannii D78 and assignment of the K4 gene cluster
Carbohydrate Research 434 (2016)
12-17
The structure of the K4 capsular polysaccharide (CPS) from a multiply antibiotic resistant Acinetobacter baumannii isolate D78 was elucidated by chemical and spectroscopical analysis. The K4 repeating unit is composed entirely by aminosugars and the trisaccharide repeating unit of the backbone polysaccharide is branched with a terminal N-acetyl-galactosamine capped with pyruvate as cyclic acetal. Each residue is in the pyranose form, alpha configured at the anomeric center, and has the D absolute configuration. The genes responsible for the synthesis of the K4 repeat unit and its polymerization and export are found in the capsule locus KL4 present in D78. The pyruvate acetal addition to galactosamine is formed by Ptr1, a novel pyruvate transferase, encoded at this locus.
NMR, structure, Acinetobacter baumannii, pyruvate acetal, CPS, Pyruvate transferase
NCBI PubMed ID: 27509201Publication DOI: 10.1016/j.carres.2016.07.016Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: C. De Castro
unina.it>
Institutions: School of Molecular Bioscience, University of Sydney, Australia, Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia, Department of Chemical Sciences, University of Napoli, Italy, Department of Agricultural Sciences, University of Napoli, Italy
Methods: 13C NMR, 1H NMR, methylation, NMR-2D, GC-MS, sugar analysis, acid hydrolysis, mild acid hydrolysis, NMR-1D, peracetylation, SEC
The publication contains the following compound(s):
Expand this publication
Collapse this publication
Total list of publication IDs on all result pages of the current query:
Total list of corresponding CSDB IDs (permanent record IDs):
Execution: 1 sec