Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: thallus
Publication DOI: 10.1177/1934578X19843610Journal NLM ID: 101477873Publisher: Natural Product Communications
Correspondence: marijanakosanic
yahoo.com
Institutions: Faculty of Science, Department of Biology and Ecology, University of Kragujevac, Serbia, Institute of Oncology and Radiology of Serbia, Belgrade, Serbia, Faculty of Science, Department of Chemistry, University of Kragujevac, Serbia
Here we determined the phenolic compounds and antioxidant, antimicrobial, genotoxic, and anticancer potential of edible mushrooms Craterellus cornucopioides. The phytochemical analysis was evaluated using high-performance liquid chromatography. Antioxidant activity was evaluated by free radical scavenging, superoxide anion scavenging, and reducing power. Craterellus cornucopioides extract had potent antioxidant activity. Further, the antimicrobial potential was determined by a microdilution method, where minimum inhibitory concentration values ranged from 0.1 to 10 mg/mL. Genotoxic potential was determined by cytokinesis block micronucleus test. The separate treatment did not show genotoxic effect, whereas the combined treatment with mitomycin C significantly reduced the micronuclei frequency in a dose-dependent manner. The highest concentration significantly reduced nuclear division index in comparison to untreated human peripheral blood lymphocytes, whereas in combined treatment, the extract did not significantly affect this parameter. Finally, the cytotoxic activity was tested using microculture tetrazolium test where measured IC50 values ranged from 65.5 to 131.7 μg/mL.
HPLC, antimicrobial, Antioxidant, cytotoxic, genotoxic, mushroom extract
Structure type: oligomer
C
27H
30O
16Location inside paper: Table 1, rutin
Trivial name: rutin, rutoside, rutin, quercetin rutinoside, rutoside, quercetin 3-O-rutinose, quercetin-3-O-rutinoside, quercetin 3-O-rutinoside
Compound class: saponin glycoside, glycoside, flavonoid glycoside, flavonol glycoside, flavone glycoside
Contained glycoepitopes: IEDB_136105,IEDB_142488,IEDB_144144,IEDB_146664,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
Methods: HPLC, extraction, CC, antioxidant activities, cytotoxicity assay, antimicrobial assay
Related record ID(s): 47960, 60082, 60204, 60258, 60341, 60396, 120171, 146364, 146678, 146810, 149316, 246660, 270705, 290867
NCBI Taxonomy refs (TaxIDs): 94199Reference(s) to other database(s): CCSD:
50720, CBank-STR:3399
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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