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Li X, Zhang X, Ye L, Kang Z, Jia D, Yang L, Zhang B
LC-MS-based metabolomic approach revealed the significantly different metabolic profiles of five commercial truffle species
Frontiers in Microbiology 10 (2019)
ID 2227
Tuber indicum
(NCBI TaxID 55307,
species name lookup)
Tuber melanosporum
(NCBI TaxID 39416,
species name lookup)
Tuber panzhihuanense
(NCBI TaxID 1263265,
species name lookup)
Tuber sinoaestivum
(NCBI TaxID 1170873,
species name lookup)
Tuber pseudoexcavatum
(NCBI TaxID 334820,
species name lookup)
Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: fruiting body
NCBI PubMed ID: 31608041Publication DOI: 10.3389/fmicb.2019.02227Journal NLM ID: 101548977Publisher: Lausanne: Frontiers Research Foundation
Correspondence: Zhang X <xiaopingzhang97
163.com>; Zhang B <690492967
qq.com>
Institutions: Soil and Fertilizer Institute, Sichuan Academy of Agricultural Sciences, Chengdu, China, Department of Microbiology, College of Resources, Sichuan Agricultural University, Chengdu, China
Truffles are ascomycetous ectomycorrhizal fungi that have elevated status in the culinary field due to their unique aroma and taste as well as their nutritional value and potential biological activities. Tuber melanosporum, T. indicum, T. panzhihuanense, T. sinoaestivum, and T. pseudoexcavatum are five commercial truffle species mainly distributed in Europe or China. In this study, an untargeted metabolomics technology based on an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was applied to analyze the metabolic profiles and variations among these five truffle species. In our results, a total of 2376 metabolites were identified under positive ion mode, of which 1282 had significantly differential amounts and covered 110 pathways or metabolisms. Principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) revealed a clear separation from each of these five truffles, indicating a significantly different metabolic profile among them, with the biggest difference between T. melanosporum and the other four truffles. The differential metabolites covered various chemical categories, and a detailed analysis was performed for nine metabolic categories, including amino acids, saccharides and nucleosides, organic acids, alkaloids, flavonoids, carnitines, phenols and alcohols, esters, and sulfur compounds. For each of the nine categories, most of metabolites predominantly accumulated in T. melanosporum compared with the other four truffles. Meanwhile, there were significant differences of the average ion intensity in each category among the five truffles, e.g., higher amounts of amino acids was detected in T. panzhihuanense and T. pseudoexcavatum; T. indicum contained significantly more carnitines, while there were more alkaloids in T. melanosporum. Additionally, some metabolites with biological activities were discussed for each category, such as acetyl-L-carnitine, adenine, neobavaisoflavone, and anandamide. Generally, this study may provide the valuable information regarding the variation of the metabolic composition of these five commercial truffle species, and the biological significance of these metabolites was uncovered to explore the metabolic mechanisms of truffles, which would be helpful for further research on the compounds and potential biological functions in truffles that have not yet been investigated.
metabolomics, bioactivity, LC-MS, truffles, edible fungus
Structure type: monomer ; 267.09621
C
10H
13N
5O
4Location inside paper: Table 3, adenosine
Trivial name: adenosine
Compound class: nucleoside
Contained glycoepitopes: IEDB_140947
Methods: DNA sequencing, ESI-MS, LC-MS, centrifugation, UHPLC-MS/MS, flame photometry
Related record ID(s): 45206, 45909, 46333, 47901, 47912, 47933, 47938, 47942, 47963, 48019, 48383, 49624, 49625, 49626, 50596, 50778, 50787, 50795, 50801, 50803, 50806, 50815
NCBI Taxonomy refs (TaxIDs): 55307,
39416,
1263265,
1170873,
334820Reference(s) to other database(s): GenDB:MN338096
Show glycosyltransferases
There is only one chemically distinct structure:
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Li X, Zhang X, Ye L, Kang Z, Jia D, Yang L, Zhang B
LC-MS-based metabolomic approach revealed the significantly different metabolic profiles of five commercial truffle species
Frontiers in Microbiology 10 (2019)
ID 2227
Tuber indicum
(NCBI TaxID 55307,
species name lookup)
Tuber melanosporum
(NCBI TaxID 39416,
species name lookup)
Tuber panzhihuanense
(NCBI TaxID 1263265,
species name lookup)
Tuber sinoaestivum
(NCBI TaxID 1170873,
species name lookup)
Tuber pseudoexcavatum
(NCBI TaxID 334820,
species name lookup)
Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: fruiting body
NCBI PubMed ID: 31608041Publication DOI: 10.3389/fmicb.2019.02227Journal NLM ID: 101548977Publisher: Lausanne: Frontiers Research Foundation
Correspondence: Zhang X <xiaopingzhang97
163.com>; Zhang B <690492967
qq.com>
Institutions: Soil and Fertilizer Institute, Sichuan Academy of Agricultural Sciences, Chengdu, China, Department of Microbiology, College of Resources, Sichuan Agricultural University, Chengdu, China
Truffles are ascomycetous ectomycorrhizal fungi that have elevated status in the culinary field due to their unique aroma and taste as well as their nutritional value and potential biological activities. Tuber melanosporum, T. indicum, T. panzhihuanense, T. sinoaestivum, and T. pseudoexcavatum are five commercial truffle species mainly distributed in Europe or China. In this study, an untargeted metabolomics technology based on an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was applied to analyze the metabolic profiles and variations among these five truffle species. In our results, a total of 2376 metabolites were identified under positive ion mode, of which 1282 had significantly differential amounts and covered 110 pathways or metabolisms. Principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) revealed a clear separation from each of these five truffles, indicating a significantly different metabolic profile among them, with the biggest difference between T. melanosporum and the other four truffles. The differential metabolites covered various chemical categories, and a detailed analysis was performed for nine metabolic categories, including amino acids, saccharides and nucleosides, organic acids, alkaloids, flavonoids, carnitines, phenols and alcohols, esters, and sulfur compounds. For each of the nine categories, most of metabolites predominantly accumulated in T. melanosporum compared with the other four truffles. Meanwhile, there were significant differences of the average ion intensity in each category among the five truffles, e.g., higher amounts of amino acids was detected in T. panzhihuanense and T. pseudoexcavatum; T. indicum contained significantly more carnitines, while there were more alkaloids in T. melanosporum. Additionally, some metabolites with biological activities were discussed for each category, such as acetyl-L-carnitine, adenine, neobavaisoflavone, and anandamide. Generally, this study may provide the valuable information regarding the variation of the metabolic composition of these five commercial truffle species, and the biological significance of these metabolites was uncovered to explore the metabolic mechanisms of truffles, which would be helpful for further research on the compounds and potential biological functions in truffles that have not yet been investigated.
metabolomics, bioactivity, LC-MS, truffles, edible fungus
Structure type: monomer ; 251.10131
C
10H
13N
5O
3Location inside paper: Table 3, 2'-deoxyadenosine
Trivial name: deoxyadenosine
Compound class: nucleoside
Methods: DNA sequencing, ESI-MS, LC-MS, centrifugation, UHPLC-MS/MS, flame photometry
Related record ID(s): 45213, 47934, 49623, 49625, 49626
NCBI Taxonomy refs (TaxIDs): 55307,
39416,
1263265,
1170873,
334820Reference(s) to other database(s): GenDB:MN338096
Show glycosyltransferases
There is only one chemically distinct structure:
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Li X, Zhang X, Ye L, Kang Z, Jia D, Yang L, Zhang B
LC-MS-based metabolomic approach revealed the significantly different metabolic profiles of five commercial truffle species
Frontiers in Microbiology 10 (2019)
ID 2227
|
b-D-Sugf-(1-9)-Subst
Sug = 5-methylthioribose = SMILES CSC[C@H]1O{1}[C@@H](O)[C@H](O)[C@@H]1O;
Subst = purine = SMILES c2ncc1nc{9}[nH]c1n2 |
Show graphically |
Tuber indicum
(NCBI TaxID 55307,
species name lookup)
Tuber melanosporum
(NCBI TaxID 39416,
species name lookup)
Tuber panzhihuanense
(NCBI TaxID 1263265,
species name lookup)
Tuber sinoaestivum
(NCBI TaxID 1170873,
species name lookup)
Tuber pseudoexcavatum
(NCBI TaxID 334820,
species name lookup)
Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: fruiting body
NCBI PubMed ID: 31608041Publication DOI: 10.3389/fmicb.2019.02227Journal NLM ID: 101548977Publisher: Lausanne: Frontiers Research Foundation
Correspondence: Zhang X <xiaopingzhang97
163.com>; Zhang B <690492967
qq.com>
Institutions: Soil and Fertilizer Institute, Sichuan Academy of Agricultural Sciences, Chengdu, China, Department of Microbiology, College of Resources, Sichuan Agricultural University, Chengdu, China
Truffles are ascomycetous ectomycorrhizal fungi that have elevated status in the culinary field due to their unique aroma and taste as well as their nutritional value and potential biological activities. Tuber melanosporum, T. indicum, T. panzhihuanense, T. sinoaestivum, and T. pseudoexcavatum are five commercial truffle species mainly distributed in Europe or China. In this study, an untargeted metabolomics technology based on an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was applied to analyze the metabolic profiles and variations among these five truffle species. In our results, a total of 2376 metabolites were identified under positive ion mode, of which 1282 had significantly differential amounts and covered 110 pathways or metabolisms. Principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) revealed a clear separation from each of these five truffles, indicating a significantly different metabolic profile among them, with the biggest difference between T. melanosporum and the other four truffles. The differential metabolites covered various chemical categories, and a detailed analysis was performed for nine metabolic categories, including amino acids, saccharides and nucleosides, organic acids, alkaloids, flavonoids, carnitines, phenols and alcohols, esters, and sulfur compounds. For each of the nine categories, most of metabolites predominantly accumulated in T. melanosporum compared with the other four truffles. Meanwhile, there were significant differences of the average ion intensity in each category among the five truffles, e.g., higher amounts of amino acids was detected in T. panzhihuanense and T. pseudoexcavatum; T. indicum contained significantly more carnitines, while there were more alkaloids in T. melanosporum. Additionally, some metabolites with biological activities were discussed for each category, such as acetyl-L-carnitine, adenine, neobavaisoflavone, and anandamide. Generally, this study may provide the valuable information regarding the variation of the metabolic composition of these five commercial truffle species, and the biological significance of these metabolites was uncovered to explore the metabolic mechanisms of truffles, which would be helpful for further research on the compounds and potential biological functions in truffles that have not yet been investigated.
metabolomics, bioactivity, LC-MS, truffles, edible fungus
Structure type: monomer ; 297.08871
C
11H
15N
5O
3S
Location inside paper: Table 3, 5'-S-methyl-5'-thioadenosine
Compound class: nucleoside
Methods: DNA sequencing, ESI-MS, LC-MS, centrifugation, UHPLC-MS/MS, flame photometry
Related record ID(s): 47963, 49623, 49624, 49626, 49698
NCBI Taxonomy refs (TaxIDs): 55307,
39416,
1263265,
1170873,
334820Reference(s) to other database(s): GenDB:MN338096
Show glycosyltransferases
There is only one chemically distinct structure:
Expand this record
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Li X, Zhang X, Ye L, Kang Z, Jia D, Yang L, Zhang B
LC-MS-based metabolomic approach revealed the significantly different metabolic profiles of five commercial truffle species
Frontiers in Microbiology 10 (2019)
ID 2227
|
a-L-Olip-(1-12)-Subst
Subst = oleandolide = SMILES C[C@H]2C[C@@]1(CO1)C(=O)[C@H](C){6}[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@H](C){12}[C@@H](O)[C@H](C){14}[C@H]2O |
Show graphically |
Tuber indicum
(NCBI TaxID 55307,
species name lookup)
Tuber melanosporum
(NCBI TaxID 39416,
species name lookup)
Tuber panzhihuanense
(NCBI TaxID 1263265,
species name lookup)
Tuber sinoaestivum
(NCBI TaxID 1170873,
species name lookup)
Tuber pseudoexcavatum
(NCBI TaxID 334820,
species name lookup)
Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: fruiting body
NCBI PubMed ID: 31608041Publication DOI: 10.3389/fmicb.2019.02227Journal NLM ID: 101548977Publisher: Lausanne: Frontiers Research Foundation
Correspondence: Zhang X <xiaopingzhang97
163.com>; Zhang B <690492967
qq.com>
Institutions: Soil and Fertilizer Institute, Sichuan Academy of Agricultural Sciences, Chengdu, China, Department of Microbiology, College of Resources, Sichuan Agricultural University, Chengdu, China
Truffles are ascomycetous ectomycorrhizal fungi that have elevated status in the culinary field due to their unique aroma and taste as well as their nutritional value and potential biological activities. Tuber melanosporum, T. indicum, T. panzhihuanense, T. sinoaestivum, and T. pseudoexcavatum are five commercial truffle species mainly distributed in Europe or China. In this study, an untargeted metabolomics technology based on an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was applied to analyze the metabolic profiles and variations among these five truffle species. In our results, a total of 2376 metabolites were identified under positive ion mode, of which 1282 had significantly differential amounts and covered 110 pathways or metabolisms. Principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) revealed a clear separation from each of these five truffles, indicating a significantly different metabolic profile among them, with the biggest difference between T. melanosporum and the other four truffles. The differential metabolites covered various chemical categories, and a detailed analysis was performed for nine metabolic categories, including amino acids, saccharides and nucleosides, organic acids, alkaloids, flavonoids, carnitines, phenols and alcohols, esters, and sulfur compounds. For each of the nine categories, most of metabolites predominantly accumulated in T. melanosporum compared with the other four truffles. Meanwhile, there were significant differences of the average ion intensity in each category among the five truffles, e.g., higher amounts of amino acids was detected in T. panzhihuanense and T. pseudoexcavatum; T. indicum contained significantly more carnitines, while there were more alkaloids in T. melanosporum. Additionally, some metabolites with biological activities were discussed for each category, such as acetyl-L-carnitine, adenine, neobavaisoflavone, and anandamide. Generally, this study may provide the valuable information regarding the variation of the metabolic composition of these five commercial truffle species, and the biological significance of these metabolites was uncovered to explore the metabolic mechanisms of truffles, which would be helpful for further research on the compounds and potential biological functions in truffles that have not yet been investigated.
metabolomics, bioactivity, LC-MS, truffles, edible fungus
Structure type: monomer ; 516.29173
C
26H
44O
10Location inside paper: Table 3, 3-O-(alpha-L-olivosyl)-oleandolide
Compound class: glycoside
Methods: DNA sequencing, ESI-MS, LC-MS, centrifugation, UHPLC-MS/MS, flame photometry
Related record ID(s): 49623, 49624, 49625
NCBI Taxonomy refs (TaxIDs): 55307,
39416,
1263265,
1170873,
334820Reference(s) to other database(s): GenDB:MN338096
Show glycosyltransferases
There is only one chemically distinct structure:
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