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Bitzer J, Henkel T, Nikiforov AI, Rihner MO, Verspeek-Rip CM, Usta B, van den Wijngaard M
Genetic toxicity studies of glycolipids from Dacryopinax spathularia
Food and Chemical Toxicology 123 (2019)
162-168
|
b-D-Glcp6Ac-(1-2)-b-D-Xylp-(1-2)-b-D-Xylp4Ac-(1-22)-Subst
Subst = 2S,17,18S,22R-tetrahydroxyhexacosanoic acid = SMILES CCCC{22}[C@@H](O)CCC{18}[C@H](O){17}C(O)CCCCCCCCCCCCCC{2}[C@H](O){1}C(O)=O |
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Dacryopinax spathularia
(previously named: Cantharellus spathularius)
(NCBI TaxID 139277,
species name lookup)
Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
NCBI PubMed ID: 30352299Publication DOI: 10.1016/j.fct.2018.10.045Journal NLM ID: 8207483Publisher: Elsevier, for BIBRA
Correspondence: anikiforov
toxregserv.com
Institutions: IMD Natural Solutions GmbH, Dortmund, Germany, Toxicology Regulatory Services, Charlottesville, USA, Charles River Laboratories (formerly WIL Research Europe B.V.), DD’s-Hertogenbosch, The Netherlands, Triskelion B.V. (formerly TNO Triskelion B.V.), Zeist, The Netherlands
A series of in vitro studies were conducted to assess the genetic toxicity of jelly mushroom glycolipids from Dacryopinax spathularia (herein referred to as "AM-1"). In the bacterial reverse mutation assay (Ames test), there was no evidence of mutagenic activity in any Salmonella typhimurium strains tested or in Escherichia coli strain WP2uvrA, at dose levels up to 5000 μg/plate. In the micronucleus (MN) test using human lymphocytes, AM-1 did not show a statistically significant increase in the number of binucleated cells containing micronuclei when compared to concurrent control cultures at all time points and at any of the concentrations analyzed (up to 900 μg/ml of culture medium). No increase in mutation frequency or numbers of small and large colonies were noted for AM-1 (up to 800 μg/ml) compared to concurrent controls when tested in the mouse lymphoma thymidine kinase assay (MLA). Therefore, AM-1 was concluded to be negative in all three assays performed both in the absence and presence of Aroclor 1254- or phenobarbital/β-naphthoflavone-induced rat liver (S9 mix) for metabolic activation. These results support the safety assessment of jelly mushroom glycolipids for potential use in food.
genetic toxicity, jelly mushroom glycolipids, natural preservative
Structure type: oligomer ; 970.53
C
46H
82O
21Location inside paper: Fig. 1, i
Compound class: glycolipid
Contained glycoepitopes: IEDB_114701,IEDB_142488,IEDB_146664,IEDB_167188,IEDB_174332,IEDB_983931,SB_192
Methods: GC-MS, NMR, biological assays, extraction, mutation analysis, cell growth, HPLC-MS, cytotoxicity assay, HPLC-ELSD, Kjeldahl method, Ames test
Related record ID(s): 49749, 49750
NCBI Taxonomy refs (TaxIDs): 139277
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There is only one chemically distinct structure:
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Bitzer J, Henkel T, Nikiforov AI, Rihner MO, Verspeek-Rip CM, Usta B, van den Wijngaard M
Genetic toxicity studies of glycolipids from Dacryopinax spathularia
Food and Chemical Toxicology 123 (2019)
162-168
|
b-D-Glcp6Ac-(1-2)-b-D-Xylp-(1-2)-b-D-Xylp4Ac-(1-21)-Subst
Subst = 2S,16R,17S,21R-tetrahydroxyhexacosanoic acid = SMILES CCCCC{21}[C@@H](O)CCC{17}[C@H](O){16}[C@H](O)CCCCCCCCCCCCC{2}[C@H](O){1}C(O)=O |
Show graphically |
Dacryopinax spathularia
(previously named: Cantharellus spathularius)
(NCBI TaxID 139277,
species name lookup)
Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
NCBI PubMed ID: 30352299Publication DOI: 10.1016/j.fct.2018.10.045Journal NLM ID: 8207483Publisher: Elsevier, for BIBRA
Correspondence: anikiforov
toxregserv.com
Institutions: IMD Natural Solutions GmbH, Dortmund, Germany, Toxicology Regulatory Services, Charlottesville, USA, Charles River Laboratories (formerly WIL Research Europe B.V.), DD’s-Hertogenbosch, The Netherlands, Triskelion B.V. (formerly TNO Triskelion B.V.), Zeist, The Netherlands
A series of in vitro studies were conducted to assess the genetic toxicity of jelly mushroom glycolipids from Dacryopinax spathularia (herein referred to as "AM-1"). In the bacterial reverse mutation assay (Ames test), there was no evidence of mutagenic activity in any Salmonella typhimurium strains tested or in Escherichia coli strain WP2uvrA, at dose levels up to 5000 μg/plate. In the micronucleus (MN) test using human lymphocytes, AM-1 did not show a statistically significant increase in the number of binucleated cells containing micronuclei when compared to concurrent control cultures at all time points and at any of the concentrations analyzed (up to 900 μg/ml of culture medium). No increase in mutation frequency or numbers of small and large colonies were noted for AM-1 (up to 800 μg/ml) compared to concurrent controls when tested in the mouse lymphoma thymidine kinase assay (MLA). Therefore, AM-1 was concluded to be negative in all three assays performed both in the absence and presence of Aroclor 1254- or phenobarbital/β-naphthoflavone-induced rat liver (S9 mix) for metabolic activation. These results support the safety assessment of jelly mushroom glycolipids for potential use in food.
genetic toxicity, jelly mushroom glycolipids, natural preservative
Structure type: oligomer ; 970.53
C
46H
82O
21Location inside paper: Fig. 1, ii
Compound class: glycolipid
Contained glycoepitopes: IEDB_114701,IEDB_142488,IEDB_146664,IEDB_167188,IEDB_174332,IEDB_983931,SB_192
Methods: GC-MS, NMR, biological assays, extraction, mutation analysis, cell growth, HPLC-MS, cytotoxicity assay, HPLC-ELSD, Kjeldahl method, Ames test
Related record ID(s): 49748, 49750
NCBI Taxonomy refs (TaxIDs): 139277
Show glycosyltransferases
There is only one chemically distinct structure:
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Bitzer J, Henkel T, Nikiforov AI, Rihner MO, Verspeek-Rip CM, Usta B, van den Wijngaard M
Genetic toxicity studies of glycolipids from Dacryopinax spathularia
Food and Chemical Toxicology 123 (2019)
162-168
|
iVl-(1-6)-b-D-Glcp-(1-2)-b-D-Xylp4Ac-(1-2)-b-D-Xylp-(1-22)-Subst
Subst = 2S,17,18S,22R-tetrahydroxyhexacosanoic acid = SMILES CCCC{22}[C@@H](O)CCC{18}[C@H](O){17}C(O)CCCCCCCCCCCCCC{2}[C@H](O){1}C(O)=O |
Show graphically |
Dacryopinax spathularia
(previously named: Cantharellus spathularius)
(NCBI TaxID 139277,
species name lookup)
Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
NCBI PubMed ID: 30352299Publication DOI: 10.1016/j.fct.2018.10.045Journal NLM ID: 8207483Publisher: Elsevier, for BIBRA
Correspondence: anikiforov
toxregserv.com
Institutions: IMD Natural Solutions GmbH, Dortmund, Germany, Toxicology Regulatory Services, Charlottesville, USA, Charles River Laboratories (formerly WIL Research Europe B.V.), DD’s-Hertogenbosch, The Netherlands, Triskelion B.V. (formerly TNO Triskelion B.V.), Zeist, The Netherlands
A series of in vitro studies were conducted to assess the genetic toxicity of jelly mushroom glycolipids from Dacryopinax spathularia (herein referred to as "AM-1"). In the bacterial reverse mutation assay (Ames test), there was no evidence of mutagenic activity in any Salmonella typhimurium strains tested or in Escherichia coli strain WP2uvrA, at dose levels up to 5000 μg/plate. In the micronucleus (MN) test using human lymphocytes, AM-1 did not show a statistically significant increase in the number of binucleated cells containing micronuclei when compared to concurrent control cultures at all time points and at any of the concentrations analyzed (up to 900 μg/ml of culture medium). No increase in mutation frequency or numbers of small and large colonies were noted for AM-1 (up to 800 μg/ml) compared to concurrent controls when tested in the mouse lymphoma thymidine kinase assay (MLA). Therefore, AM-1 was concluded to be negative in all three assays performed both in the absence and presence of Aroclor 1254- or phenobarbital/β-naphthoflavone-induced rat liver (S9 mix) for metabolic activation. These results support the safety assessment of jelly mushroom glycolipids for potential use in food.
genetic toxicity, jelly mushroom glycolipids, natural preservative
Structure type: oligomer ; 1012.58
C
49H
88O
21Location inside paper: Fig. 1, iii
Compound class: glycolipid
Contained glycoepitopes: IEDB_114701,IEDB_142488,IEDB_146664,IEDB_167188,IEDB_174332,IEDB_983931,SB_192
Methods: GC-MS, NMR, biological assays, extraction, mutation analysis, cell growth, HPLC-MS, cytotoxicity assay, HPLC-ELSD, Kjeldahl method, Ames test
Related record ID(s): 49748, 49749
NCBI Taxonomy refs (TaxIDs): 139277
Show glycosyltransferases
There is only one chemically distinct structure:
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