Taxonomic group: fungi /
NCBI PubMed ID: 31671548Publication DOI: 10.3390/cells8111348Journal NLM ID: 101600052Publisher: Basel, Switzerland: MDPI
Correspondence: Lee DJ <danielle.lee2
griffithuni.edu.au>; O'Donnell H <holly.odonnell
griffithuni.edu.au>; Routier FH <Routier.francoise
mh-hannover.de>Tiralongo J <j.tiralongo
griffith.edu.au>; Haselhorst T <t.haselhorst
griffith.edu.au>
Institutions: Institute for Glycomics, Griffith University, Queensland, Australia, Member of Fraunhofer International Consortium for Anti-Infective Research (iCAIR), Hannover, Germany, Department of Clinical Biochemistry OE4340, Hannover Medical School, Hannover, Germany
Invasive fungal infections (IFI) are an increasing threat to the developing world, with fungal spores being ubiquitous and inhaled every day. Some fungal species are commensal organisms that are part of the normal human microbiota, and, as such, do not pose a threat to the immune system. However, when the natural balance of this association is disturbed or the host's immune system is compromised, these fungal pathogens overtake the organism, and cause IFI. To understand the invasiveness of these pathogens and to address the growing problem of IFI, it is essential to identify the cellular processes of the invading organism and their virulence. In this review, we will discuss the prevalence and current options available to treat IFI, including recent reports of drug resistance. Nevertheless, the main focus of this review is to describe the glycobiology of human fungal pathogens and how various components of the fungal cell wall, particularly cell wall polysaccharides and glycoconjugates, are involved in fungal pathogenicity, their biosynthesis and how they can be potentially exploited to develop novel antifungal treatment options. We will specifically describe the nucleotide sugar transporters (NSTs) that are important in fungal survival and suggest that the inhibition of fungal NSTs may potentially be useful to prevent the establishment of fungal infections.
UDP-galactofuranose, Candida, Aspergillus, GDP-mannose, Cryptococcus, nucleotide sugar transporter, immunosuppression, invasive fungal infection, UDP-glucuronic acid, UDP-xylose
Structure type: homopolymer
Location inside paper: Fig. 2, d
Aglycon: β-1,3-glucan
Trivial name: chitin
Compound class: glucan, polysaccharide
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531,IEDB_153212,IEDB_241099,IEDB_423114,IEDB_423150,SB_74,SB_85
Related record ID(s): 50302, 50305, 50306, 50309, 50312, 50313, 50316, 50318
NCBI Taxonomy refs (TaxIDs): 4751Reference(s) to other database(s): GTC:G97099AY
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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