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1. (Article ID: 5007)
Kenyon JJ, Notaro A, Hsu LY, De Castro C, Hall RM
5,7-Di-N-acetyl-8-epiacinetaminic acid: A new non-2-ulosonic acid found in the K73 capsule produced by an Acinetobacter baumannii isolate from Singapore
Scientific Reports 7(1) (2017)
11357
Nonulosonic acids are found in the surface polysaccharides of many bacterial species and are often implicated in pathogenesis. Here, the structure of a novel 5,7-diacetamido-3,5,7,9-tetradeoxynon-2-ulosonic acid recovered from the capsular polysaccharide of a multiply antibiotic resistant Acinetobacter baumannii isolate was determined. The isolate carries a sugar synthesis module that differs by only a single gene from the module for the synthesis of 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-L-altro-non-2-ulosonic acid or 5,7-di-N-acetylacinetaminic acid, recently discovered in the capsule of another A. baumannii isolate. The new monosaccharide is the C8-epimer of acinetaminic acid (8eAci; 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-L-altro-non-2-ulosonic acid) and the C7-epimer of legionaminic acid. This monosaccharide had not previously been detected in a biological sample but had been synthesized chemically.
structure, Acinetobacter baumannii, capsular polysaccharide, nonulosonic acid, 5, 7, 7-diacetamido-3, legionaminic acid, capsule, surface polysaccharide, 7-Di-N-acetyl-8-epiacinetaminic acid, 9-tetradeoxy-D-glycero-L-altro-non-2-ulosonic acid
NCBI PubMed ID: 28900250Publication DOI: 10.1038/s41598-017-11166-4Journal NLM ID: 101563288Publisher: London: Nature Publishing Group
Correspondence: decastro
unina.it; ruth.hall
sydney.edu.au
Institutions: Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia, School of Life and Environmental Sciences, The University of Sydney, Sydney, Australia, Department of Chemical Sciences, University of Napoli, Naples, Italy, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore, Singapore, Department of Agricultural Sciences, University of Napoli, Naples, Italy
Methods: 13C NMR, 1H NMR, methylation, NMR-2D, DNA sequencing, GC-MS, enzymatic hydrolysis, mild acid hydrolysis, composition analysis, bioinformatic analysis, SEC
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