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1. (Article ID: 5009)
Kenyon JJ, Kasimova AA, Notaro A, Arbatsky NP, Speciale I, Shashkov AS, De Castro C, Hall RM, Knirel YA
Acinetobacter baumannii K13 and K73 capsular polysaccharides differ only in K-unit side branches of novel non-2-ulosonic acids: di-N-acetylated forms of either acinetaminic acid or 8-epiacinetaminic acid
Carbohydrate Research 452 (2017)
149-155
Structures of capsular polysaccharides of Acinetobacter baumannii isolates carrying KL13 and KL73 gene clusters were established. The closely related KL73 and KL13 gene clusters differ only by one gene in the module responsible for synthesis of the non-2-ulosonic acids. The K13 and K73 polysaccharides differ only in a single side-chain sugar, which is either 5,7-diacetamido-3,5,7,9-tetradeoxy-l-glycero-l-altro- or -d-glycero-l-altro-non-2-ulosonic acid [di-N-acetylated forms of acinetaminic acid (Aci5Ac7Ac) or 8-epiacinetaminic acid (8eAci5Ac7Ac), respectively]. The KL13 also is closely related to the KL12 gene cluster, which contains a different wzy gene encoding the K unit polymerase. Accordingly, the otherwise near identical K units are linked differently via an α-d-FucpNAc-(1→4)-d-Galp linkage in K13 and K73 or an α-d-FucpNAc-(1→3)-d-GalpNAc linkage in K12. This finding confirms the predicted substrate of the ItrB3 initiating transferase as d-FucpNAc. Glycosyltransferases predicted to catalyse the linkage of d-Galp or d-GalpNAc to l-FucpNAc in the growing K13 and K73 or K12 units, respectively, differ by only two amino acids.
Acinetobacter baumannii, capsular polysaccharide, capsular polysaccharide structure, 5, 7-Di-N-acetyl-8-epiacinetaminic acid, Capsule biosynthesis gene cluster, Non-2-ulosonic acid 5, 7-Di-N-acetylacinetaminic acid
NCBI PubMed ID: 29100177Publication DOI: 10.1016/j.carres.2017.10.005Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: decastro
unina.it; ruth.hall
sydney.edu.au
Institutions: N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia, School of Life and Environmental Sciences, The University of Sydney, Sydney, Australia, Higher Chemical College of the Russian Academy of Sciences, D. I. Mendeleev University of Chemical Technology of Russia, Moscow, Russia, Department of Chemical Sciences, University of Naples, Naples, Italy, Department of Agricultural Sciences, University of Naples, Naples, Italy
The publication contains the following compound(s):
- Compound ID: 12580
Structure type: polymer chemical repeating unit
Compound class: CPS
Reference(s) to other database(s): GTC:G21341UC
- Compound ID: 12581
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a-Acip5Ac7Ac-(2-6)-+
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-4)-a-D-Galp-(1-3)-a-L-FucpNAc-(1-3)-a-D-FucpNAc-(1- |
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Structure type: polymer chemical repeating unit
Trivial name: K13 CPS
Compound class: CPS
Reference(s) to other database(s): GTC:G01535IF
- Compound ID: 12582
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a-8eAcip5Ac7Ac-(2-6)-+
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-4)-a-D-Galp-(1-3)-a-L-FucpNAc-(1-3)-a-D-FucpNAc-(1- |
Show graphically |
Structure type: polymer chemical repeating unit
Trivial name: K73 CPS
Compound class: CPS
Reference(s) to other database(s): GTC:G69727CP
- Compound ID: 12583
|
a-Acip5Ac7Ac-(2-6)-+
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-3)-a-D-GalpNAc-(1-3)-a-L-FucpNAc-(1-3)-a-D-FucpNAc-(1- |
Show graphically |
Structure type: polymer chemical repeating unit
Trivial name: K12 CPS
Compound class: CPS
Reference(s) to other database(s): GTC:G90675WE
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