Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: aerial part
NCBI PubMed ID: 9270375Publication DOI: 10.1055/s-2006-957690Journal NLM ID: 0066751Publisher: George Thieme
Institutions: Pharmacognosy Division, Department of Pharmacy, University of Helsinki, Helsinki, Finland
The ethyl acetate and n-butanol fractions from aerial parts of E. hunanense were initially screened to find active fractions with immunomodulatory activity. Nine compounds, tricin (1), luteolin (2), thalictoside (3), icariin I (4), baohuoside I (5), quercitrin (6), icariin (7), epimedin C (8), and B (9) were isolated from this species for the first time, and 3 was isolated for the first time from flavonoid extracts of the genus. Their structures were established by chemical and spectroscopic methods. The immunomodulatory effects of the n-butanol fraction and epimedin C isolated from the fraction were investigated. Hydrocortisone acetate (HCA) was used as an immunosuppressant to inhibit the immune response of mice. The n-butanol fraction and epimedin C significantly enhanced the response of spleen antibody-forming cells (SAFC) to near normal in the mice treated with HCA. They also significantly enhanced lymphocyte proliferation and caused a significant recovery of interleukin-2 (IL-2) production in the mice inhibited with HCA. In conclusion, they are active principles with immunoenhancing effects.
flavonol glycosides, Epimedium hunanense, immunoenhancing effect, spleen antibody-forming cells (SAFC)
Structure type: monomer
C
21H
20O
11Location inside paper: abstract
Trivial name: quercitrin, baohuoside-II, quercetin 3-rhamnoside, quercetin 3-O-rhamnoside
Compound class: saponin glycoside, glycoside, flavonoid glycoside, flavonol glycoside
Contained glycoepitopes: IEDB_136105,IEDB_225177,IEDB_885823
Methods: 13C NMR, 1H NMR, IR, FAB-MS, biological assays, radiolabeling, radioactivity measurement, HPLC, UV, extraction, CC, cytokine production, centrifugation, recrystallization
Related record ID(s): 50528, 50529, 50531, 50532, 50533
NCBI Taxonomy refs (TaxIDs): 471939Reference(s) to other database(s): CCSD:
49971, CBank-STR:599
Show glycosyltransferases
There is only one chemically distinct structure:
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