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1. (Article ID: 5187)
 
Ménová P, Sella M, Sellrie K, Pereira C, Seeberger PH
Identification of the minimal glycotope of Streptococcus pneumoniae 7F capsular polysaccharide using synthetic oligosaccharides
Chemistry: a European Journal 24(16) (2018) 4181-4187
 

Streptococcus pneumoniae causes life-threatening diseases including meningitis, pneumonia and sepsis. Existing glycoconjugate vaccines based on purified capsular polysaccharides are widely used and help to prevent millions of deaths every year. Here, we report total synthesis of oligosaccharides resembling portions of the S. pneumoniae serotype 7F (ST7F) capsular polysaccharide repeating unit. To define minimal glycan epitopes, glycan microarrays containing the synthetic oligosaccharides were used to screen human reference serum and revealed that both side chains of the ST7F play a key role in antigen recognition. The identification of protective minimal epitopes is vital to design efficient semi- and fully-synthetic glycoconjugate vaccines.

Streptococcus pneumoniae, total synthesis, Glycan arrays, minimal glycotopes, serotype 7F

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