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1. (Article ID: 5286)
 
Kiho T, Yoshida I, Nagai K, Ukai S, Hara C
(1→3)-α-D-glucan from an alkaline extract of Agrocybe cylindracea, and antitumor activity of its O-(carboxymethyl)ated derivatives
Carbohydrate Research 189(C) (1989) 273-279
 

The structure of an alkali-soluble D-glucan (AG-AL) from the fruit body of Agrocybe cylindracea was investigated by a combination of chemical and spectroscopic methods indicating that it was a linear (1→3)-α-D-glucan (molecular weight, ~560,000), [α]D2O +195° (c 0.5, m sodium hydroxide). Both water-soluble and gelatinous products obtained by O-(carboxymethyl)ation of AG-AL showed potent antitumor activity against the solid form of Sarcoma 180 in mice, although the native D-glucan had little effect on the tumor.

mice, glucan, sarcoma 180, Agrocybe cylindracea, carboxymethylated derivative

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