A new glycopeptide antibiotic, balhimycin, has been isolated from the fermentation broth of a Amycolatopsis sp. Y-86,21022. Balhimycin belongs to the vancomycin class of glycopeptides and contains a dehydrovancosamine sugar. The biological activity of balhimycin has been compared extensively with that of vancomycin against methicillin resistant staphylococci and also against anaerobes. Balhimycin is marginally superior to vancomycin in its in vitro activity against anaerobes and in its bactericidal properties.

glycopeptide, antibiotic, balhimycin, Amycolatopsis sp.

• Compound ID: 13468
  

  b-D-Glcp-(1-1)-Subst-(2-1)-a-D-Sugp Subst = balhimycin aglycon = SMILES CN[C@H](CC(C)C)C(=O)N[C@H]6C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]4C(=O)N[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c1cc(O)cc(O)c1c3cc2ccc3O){2}[C@H:1](O)c8ccc(Oc7cc4cc(Oc5ccc(cc5Cl)[C@H]6O){1}c7O)c(Cl)c8; Sug = 3-amino-2,3,6-trideoxy-3-C-methyl-L-lyxo-hexos-4-ulose (dehydrovancosamine) = SMILES C[C@@H]1O{1}[C@@H](O)C[C@](C)(N)C1=O

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  Structure type: oligomer
  Trivial name: balhimycin
  Compound class: glycoside
  Reference(s) to other database(s): GTC:G34375YG
  
   
  
  Amycolatopsis sp. Y-86,21022 DSM 5908
  CSDB ID 46019 (all data & tools)