The structure of the two factors of the novel glycopeptide antibiotic A40926 have been determined using a combination of FAB-MS, GC-MS and 1H NMR studies. A40926 Is a member of the vancomycin family of antibiotics and is structurally related to teicoplanin, A35512B and aridicin

glycopeptide, Actinomadura, antibiotic, Vancomycin, teicoplanin, aridicin

• Compound ID: 14222
  

  a-D-Manp-(1-1)-+ | Udo-(1-2)-a-D-GlcpNA-(1-2)-Subst Subst = SMILES CN[C@H]6C(=O)N[C@@H]4Cc1ccc(cc1)Oc%11cc3cc(Oc2ccc(cc2Cl)C(O)C%10NC(=O)[C@H](NC(=O)[C@@H]3NC(=O)[C@@H](NC4=O)c5cc(cc(O)c5Cl)Oc7cc6ccc7O)c8cccc(c8)c9{1}c(O)cc(O)cc9[C@@H](C(=O)O)NC%10=O){2}c%11O

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  Structure type: oligomer ; 1717 [M+H]+
  Trivial name: A40926
  Compound class: glycoside
  
   
  
  Actinomadura sp. ATCC 39726
  CSDB ID 47735 (all data & tools)
• Compound ID: 14223
  

  a-D-Manp-(1-1)-+ | Subst2-(1-2)-a-D-GlcpNA-(1-2)-Subst Subst = SMILES CN[C@H]6C(=O)N[C@@H]4Cc1ccc(cc1)Oc%11cc3cc(Oc2ccc(cc2Cl)C(O)C%10NC(=O)[C@H](NC(=O)[C@@H]3NC(=O)[C@@H](NC4=O)c5cc(cc(O)c5Cl)Oc7cc6ccc7O)c8cccc(c8)c9{1}c(O)cc(O)cc9[C@@H](C(=O)O)NC%10=O){2}c%11O; Subst2 = isolauric acid = SMILES CC(C)CCCCCCCC{1}C(=O)O

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  Structure type: oligomer ; 1731 [M+H]+
  Trivial name: A40926
  Compound class: glycoside
  
   
  
  Actinomadura sp. ATCC 39726
  CSDB ID 47736 (all data & tools)