Two new antiinflammatory macrolides, lobophorins A and B (1 and 2), have been isolated from fermentation broths of a marine bacterium isolated from the surface the Caribbean brown alga Lobophora variegata (Dictyotales). The new compounds, distantly related to antibiotics of the kijanimicin class, are potent inhibitors of topical PMA-induced edema in the mouse ear assay when administered either topically or IP

lobophorins, antiinflammatory activity, Lobophora variegata

• Compound ID: 14313
  

  Subst2-(1-4)-b-D-Sugp-(1-17)-+ | b-L-Digp4Me-(1-4)-a-L-Digp-(1-3)-a-L-Digp-(1-9)-Subst Sug = 3C-methyl-3,4-diamino-2,3,4,6-tetradeoxy-xylo-hexose = SMILES C[C@H]1O{1}[C@@H](O)C[C@](C)(N){4}[C@H]1N; Subst = kijanolide = SMILES C/C3=C/C{17}[C@H](O)/C(C)=C\[C@H]1\C=C(CO)/[C@H](C)C[C@]12OC(=O)/C(=C2/O)C(=O)[C@]5(C)[C@H]3/C=C\[C@@H]4{9}[C@@H](O)[C@@H](C)C[C@H](C)[C@H]45; Subst2 = carbamic acid methyl ester = SMILES CO{1}C(N)=O

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  Structure type: oligomer
  Trivial name: lobophorin A
  Compound class: glycoside
  
   
  
  (Actinomycetaceae) sp. CNB-837
  CSDB ID 48087 (all data & tools)
• Compound ID: 14314
  

  Subst2-(1-4)-b-D-Sugp-(1-17)-+ | b-L-Digp4Me-(1-4)-a-L-Digp-(1-3)-a-L-Digp-(1-9)-Subst Sug = 3C-methyl-3-nitro-4-amino-2,3,4,6-tetradeoxy-xylo-hexose = SMILES C[C@H]1O{1}[C@@H](O)C[C@](C)(N(=O)=O){4}[C@H]1N; Subst = kijanolide = SMILES C/C3=C/C{17}[C@H](O)/C(C)=C\[C@H]1\C=C(CO)/[C@H](C)C[C@]12OC(=O)/C(=C2/O)C(=O)[C@]5(C)[C@H]3/C=C\[C@@H]4{9}[C@@H](O)[C@@H](C)C[C@H](C)[C@H]45; Subst2 = carbamic acid methyl ester = SMILES CO{1}C(N)=O

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  Structure type: oligomer
  Trivial name: lobophorin B
  Compound class: glycoside
  
   
  
  (Actinomycetaceae) sp. CNB-837
  CSDB ID 48088 (all data & tools)