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1. (Article ID: 5660)
Kiho T, Yoshida I, Katsuragawa M, Sakushima M, Usui S, Ukai S
Polysaccharides in Fungi. XXXIV. A polysaccharide from the fruiting bodies of Amanita muscaria and the antitumor activity of its carboxymethylated product
Biological and Pharmaceutical Bulletin 17(11) (1994)
1460-1462
A water-insoluble, alkali-soluble, glucan (AM-APP), [α]D +160° in 0.4 M NaOH, was isolated from the alkaline extract of the fruiting bodies of Amanita muscaria. The results of chemical and spectroscopic investigations indicate that AM-APP is a linear (1→3)-α-D-glucan with a molecular weigh estimated by gel chromatography of about 42000. Its carboxymethylated product (AM-APP-CM) showed potent antitumor activity against sarcoma 180 in mice, although the native polysaccharide (AM-APP) had little effect. The distribution of carboxymethyl groups in the molecule was analyzed by gas chromatography and mass spectrometry. The degree of substitution of carboxymethyl groups was 0.95 and the substituents were located at O-2, at O-4, at O-6, at O-2 and O-6, and at O-4 and O-6 on glucose
polysaccharide, antitumor activity, (1→3)-α-D-glucan, Amanita muscaria, carboxymethyl group
NCBI PubMed ID: 7703963Publication DOI: 10.1248/bpb.17.1460Journal NLM ID: 9311984Publisher: Pharmaceutical Society of Japan
Institutions: Gifu Pharmaceutical University, Gifu, Japan
Methods: 13C NMR, methylation, GC-MS, acid hydrolysis, GC, GPC, extraction, acetylation, methylation analysis, reduction, dialysis, derivatization, antitumor activity assay
The publication contains the following compound(s):
- Compound ID: 14324
Structure type: homopolymer
; n=540
Trivial name: β-(1,3)-glucan, curdlan
Compound class: glucan, polysaccharide
Reference(s) to other database(s): GTC:G51056AN
- Compound ID: 14325
Structure type: structural motif or average structure
; n=540
- Compound ID: 21144
|
?%Gc-(2-6)-+
|
?%Gc-(2-2)-+ |
| |
-3)-a-D-Glcp-(1-
|
?%Gc-(2-4)-+ |
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Structure type: structural motif or average structure
- Compound ID: 21143
Structure type: homopolymer
; 42000
Trivial name: α-(1,3)-glucan, curdlan
Compound class: glucan, polysaccharide
Reference(s) to other database(s): GTC:G02177KX
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