The beta-elimination procedure was used to obtain two major fragments of Mycobacterium avium glycopeptidolipid antigens. The lipopeptide fragment, not the oligosaccharide, diminished the mitogen-induced blastogenic response of spleen cells at concentrations lower than those which affected viability. Electron microscopy revealed an internalization of lipopeptide and disruption of intracellular organization.
NCBI PubMed ID: 1730507Journal NLM ID: 0246127Publisher: American Society for Microbiology
Institutions: Department of Microbiology and Immunology, Texas College of Osteopathic Medicine, Fort Worth 76107-2690