Found 2 publications.
Displayed publications from 1 to 2
Expand all publications
Collapse all publications
Show all as text (SweetDB notation)
Show all graphically (SNFG notation)
1. (Article ID: 5925)
Ferguson MAJ, Hart GW, Kinoshita T
Glycosylphosphatidylinositol Anchors
Book: In: Essentials of Glycobiology [Internet] (2017)
Plasma membrane proteins are either peripheral proteins or integral membrane proteins. The latter include proteins that span the lipid bilayer once or several times, and another class that are covalently attached to lipids. Proteins attached to glycosylphosphatidylinositol (GPI) via their carboxyl termini are generally found in the outer leaflet of the lipid bilayer and face the extracellular environment. The GPI membrane anchor may be conveniently thought of as an alternative to the single transmembrane domain of type-1 integral membrane proteins. This chapter reviews the discovery, distribution, structure, biosynthesis, properties, and suggested functions of GPI membrane anchors and related molecules.
proteins, Glycosylphosphatidylinositol, glycobiology, GPI, membrane protein
NCBI PubMed ID: 28876821Publication DOI: 10.1101/glycobiology.3e.012Publisher: Cold Spring Harbor (NY), Cold Spring Harbor Laboratory Press
Editors: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH
Correspondence: majferguson
dundee.ac.uk
Institutions: Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Science, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom, Johns Hopkins University, Baltimore, Maryland, USA, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
The publication contains the following compound(s):
- Compound ID: 15244
Structure type: structural motif or average structure
Trivial name: type-1 GIPI
Compound class: glycoinositol phospholipid
- Compound ID: 15245
Structure type: structural motif or average structure
Trivial name: type-2 GIPI
Compound class: glycoinositol phospholipid
- Compound ID: 15246
|
a-D-Manp-(1-6)-a-D-Manp-(1-3)-a-D-Manp-(1-4)-a-D-GlcpN-(1-6)-L-myoIno-(1-P |
Show graphically |
Structure type: structural motif or average structure
Trivial name: hybrid GIPI
Compound class: glycoinositol phospholipid
- Compound ID: 15243
|
?%LIP-(1-2)-+ /Variants 0/-+
| |
Subst-(1-2)-EtN-(1--P--6)--a-D-Manp-(1-2)-a-D-Manp-(1-6)-a-D-Manp-(1-4)-a-D-GlcpN-(1-6)-L-myoIno-(1--P--3)--Gro
|
LIP-(1-2)-+
/Variants 0/ is:
LIP-(1-1)-
OR (exclusively)
ALK-1)-
Subst = protein |
Show graphically |
Structure type: oligomer
Trivial name: common core of GPI anchors
Compound class: GPI-anchor
Expand this publication
Collapse this publication
2. (Article ID: 6010)
Swarts BM, Guo ZW
Chemical synthesis and functionalization of clickable glycosylphosphatidylinositol anchors
Chemical Science 2(12) (2011)
2342-2352
Glycosylphosphatidylinositol (GPI) anchorage is a common posttranslational modification of eukaryotic proteins. Chemical synthesis of structurally defined GPIs and GPI derivatives is a necessary step toward understanding the properties and functions of these molecules in biological systems. In this work, the synthesis of several functionalized GPI anchors was accomplished using the paramethoxybenzyl (PMB) group for permanent hydroxyl protection, which allowed the incorporation of functionalities that are incompatible with permanent protecting groups traditionally used in carbohydrate synthesis. A flexible convergent-divergent assembly strategy enabled efficient access to a diverse set of target structures, including 'clickable'' alkyne- and azide-modified GPIs. For global deprotection, a one-pot reaction was employed to afford the target GPIs in excellent yields (85-97%). Fully deprotected clickable GPI derivatives were readily conjugated to imaging and affinity probes via Cu(I)-catalyzed and Cu-free strain-promoted [3 + 2] cycloaddition to result in GPI-Flour and GPI-Biotin conjugates, respectively.
synthesis, carbohydrate, proteins, Glycosylphosphatidylinositol, GPI, GPI anchor
Publication DOI: 10.1039/C1SC00440aJournal NLM ID: 101545951Publisher: Cambridge, UK: Royal Society of Chemistry
Correspondence: zwguo
chem.wayne.edu
Institutions: Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan, USA
Methods: 13C NMR, 1H NMR, TLC, 31P NMR, chemical synthesis, MALDI-TOF MS, UV, optical rotation measurement, SEC, CC, conjugation
The publication contains the following compound(s):
Expand this publication
Collapse this publication
Total list of publication IDs on all result pages of the current query:
Total list of corresponding CSDB IDs (permanent record IDs):
Execution: 1 sec