Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: root
The structure was elucidated in this paperNCBI PubMed ID: 9720608Publication DOI: 10.1016/s0378-8741(98)00030-0Journal NLM ID: 7903310Publisher: Limerick: Elsevier Sequoia
Institutions: Cátedra de Inmunología-IDEHU, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina, Cátedra de Farmacobotánica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina, Museo de Farmacobotánica ‘Juan A. Domı´nguez’, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina, Research Career, CONICET, Facultad de Farmacia y Bioquímica, Uni6ersidad de Buenos Aires, Buenos Aires, Argentina
Ligaria cuneifolia (R. et P.) Tiegh, is an hemiparasite species used in Argentine folk medicine as a substitute for the European mistletoe (Viscum album L.) based on its putative activity of decreasing high blood pressure. This paper analyzes flavonoid composition, protein constituents and the possible immunomodulatory and antitumoral effects of this species. Micromolecular study disclosed quercetin-free, quercetin-glycosylated and proanthocyanidins corresponding to cyanidin monomers, which implies a particular metabolic pathway. Proteins present in L. cuneifolia extracts analyzed by SDS-PAGE presented multiple bands with molecular weights ranging from 14 to 90 kD. These features contribute to the characterization of the native mistletoe. As V. album is being used in cancer treatment due to its immunomodulatory and antitumoral activity, the action of aqueous L. cuneifolia extracts on murine lymphocytes was investigated. Culture of murine spleen cells alone or stimulated with Concanavalin A or lipopolysaccharide in presence of L. cuneifolia extracts indicated a certain stimulation of splenocytes alone and an inhibition of splenocytes stimulated with Concanvalin A or lipopolysaccharide. An inhibitory effect was also observed on the proliferation of murine leukemia cells. In addition, aqueous extracts increased nitric oxide production by murine macrophages. These results suggest that L. cuneifolia extracts exert an immunomodulatory effect on the mouse immune system.
expression, immunity, lectin, apoptosis, tumor, quercetin, in-vitro, blood mononuclear-cells, balb/c-mice, system
Structure type: monomer
Location inside paper: p. 28, column 2, paragraph 3
Compound class: glycoside
Contained glycoepitopes: IEDB_114701,IEDB_136105,IEDB_167188,IEDB_174332,IEDB_225177,IEDB_885823
Methods: TLC, extraction, chromatography, HP-TLC
NCBI Taxonomy refs (TaxIDs): 50140
Show glycosyltransferases
There is only one chemically distinct structure:
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