Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: aerial part
NCBI PubMed ID: 10385216Publication DOI: 10.1211/0022357991772484Journal NLM ID: 0376363Publisher: London: Pharmaceutical Society of Great Britain; West Sussex: Wiley
Institutions: Department of Pharmacology of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110015, China, Department of Chemistry for Nature Products, Shenyang Pharmaceutical University, Shenyang 110015, China
This study assessed the effects of pseudoginsenoside F11, a component of Panax quinquefolium L., on scopolamine-impaired memory performance in mice and rats. In the one-trial step-down and step-through passive avoidance tests, although pseudoginsenoside F11 used alone did not affect passive avoidance behaviour in naive mice, the latency of avoidance shortened by intraperitoneal scopolamine (2 mg kg-1) was prolonged after intragastric administration of pseudoginsenoside F11 (2 or 4 mg kg-1, for five days) in both test systems in mice. In the water-maze test, in mice, the time taken to locate the platform after administration of pseudoginsenoside F11 was shorter than that after administration of scopolamine (1 mg kg-1, i.p.). In the two-way active avoidance response test, the latency of avoidance was significantly shorter for the pseudoginsenoside F11- (1.2 or 2.4 mg kg-1, i.g. for five days) and scopolamine-treated group than for the group of rats given scopolamine only (2 mg kg-1, i.p.). The percentage avoidance was also reduced after intraperitoneal injection of scopolamine, but was reversed by administration of pseudoginsenoside F11. These results suggest that pseudoginsenoside F11 antagonized the memory dysfunction induced by scopolamine. However, the mechanism of the memory facilitative action of pseudoginsenoside F11 merits further elucidation.
Panax quinquefolium, pseudoginsenoside F11, memory dysfunction
Structure type: oligomer
Location inside paper: fig. 1, pseudoginsenoside F11
Trivial name: pseudoginsenoside F11, 24(R)-pseudoginsenoside F11
Compound class: saponin glycoside, glycoside
Contained glycoepitopes: IEDB_136105,IEDB_142488,IEDB_144144,IEDB_146664,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
Methods: statistical analysis, memory dysfunction assay
Biological activity: Pseudoginsenoside F11 can significantly antagonize scopolamine-induced memory impairment in passive and active avoidance tests in male Swiss mice.
NCBI Taxonomy refs (TaxIDs): 44588
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There is only one chemically distinct structure:
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