Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: whole plant
NCBI PubMed ID: 10624901Publication DOI: 10.1016/S0378-8741(99)00122-1Journal NLM ID: 7903310Publisher: Limerick: Elsevier Sequoia
Institutions: University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, India, G. Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad 500 028, India
The phytochemical study using Caralluma umbellata (Asclepiadaceae) whole plant allowed the isolation of a novel pregnane glycoside named carumbelloside I (3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-3β,14β-dihydroxypregn-5-en-20-one). Carumbelloside I was evaluated for both antinociceptive activity and anti-inflammatory activity. The antinociceptive activity was evaluated in mice using the writhing test method, while the anti-inflammatory activity was evaluated in rats using the paw edema test with carrageenin. Carumbelloside I has significant antinociceptive action. It has no anti-inflammatory activity.
Asclepiadaceae, pregnane glycoside, Caralluma umbellata, antinociceptive activityAnti-inflammatory activity, carumbelloside-I, 3-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-3β, 14β-dihydroxypregn-5-en-20-one
Structure type: oligomer
Location inside paper: carumbelloside I, compound 1, fig. 1, CU-I
Trivial name: carumbelloside I
Compound class: saponin glycoside, glycoside
Contained glycoepitopes: IEDB_141806,IEDB_142488,IEDB_146664,IEDB_241101,IEDB_983931,SB_192
Methods: statistical analysis, anti-inflammation assay, antinociception assay, writhing test
Biological activity: Carumbelloside I demonstrated dose-dependent antinociceptive activity toward acetic acid-induced writhings in mice with inhibition rates of 35.95, 44.32 and 55.68% at 1, 3, 10 mg/kg doses, respectively.
NCBI Taxonomy refs (TaxIDs): 197243Reference(s) to other database(s): CCSD:
39043, CBank-STR:4192
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There is only one chemically distinct structure:
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(later renamed to: Boucerosia umbellata)