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1. (Article ID: 6297)
 
Qi M, Zheng C, Wu W, Yu G, Wang P
Exopolysaccharides from Marine Microbes: Source, Structure and Application
Marine Drugs 20(8) (2022) 512
 

The unique living environment of marine microorganisms endows them with the potential to produce novel chemical compounds with various biological activities. Among them, the exopolysaccharides produced by marine microbes are an important factor for them to survive in these extreme environments. Up to now, exopolysaccharides from marine microbes, especially from extremophiles, have attracted more and more attention due to their structural complexity, biodegradability, biological activities, and biocompatibility. With the development of culture and separation methods, an increasing number of novel exopolysaccharides are being found and investigated. Here, the source, structure and biological activities of exopolysaccharides, as well as their potential applications in environmental restoration fields of the last decade are summarized, indicating the commercial potential of these versatile EPS in different areas, such as food, cosmetic, and biomedical industries, and also in environmental remediation.

structure, exopolysaccharides, EPS, marine microorganisms, biological activities, environmentalremediation

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2. (Article ID: 8615)
 
Li H, Cao K, Cong P, Liu Y, Cui H, Xue C
Structure characterization and antitumor activity of the extracellular polysaccharide from the marine fungus Hansfordia Sinuosae
Carbohydrate Polymers 190 (2018) 87-94
 

A neutral water soluble polysaccharide (HPA) was isolated from the marine fungus Hansfordia sinuosae. Monosaccharide composition analysis indicated that HPA was mainly composed of mannose with minor amounts of galactose and glucose. The molecular weight of HPA was approximately 22.5 kDa as analyzed by HPGPC. Structure analysis of HPA with methylation and 1D, 2D NMR indicated that HPA was composed of [α-D-Manp(1→], [→2)-α-D-Manp(1→], [→3)-α-D-Manp(1→] and [→2,6)-α-D-Manp(1→] with [α-D-Manp(1→] linked to C-6 position of [→2,6)-α-D-Manp(1→]. The antitumor effect of HPA was evaluated in vitro. HPA showed remarkable inhibitory effect on human cervical carcinoma HeLa cells and human breast carcinoma MCF-7 cells. When cells were incubated with HPA at 400 μg/mL for 48 h, the inhibition rate on HeLa and MCF-7 cells was 79.5% and 73.8%, respectively. Furthermore, for HeLa cells, HPA could increase intracellular ROS levels, induce cells apoptosis, decrease mitochondrial membrane potential, and elevate the expression of caspase-3. The results suggested that HPA could be explored as a potential antitumor agent.

structure, extracellular polysaccharide, apoptosis, antitumor activity, Hansfordia sinuosae

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