Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: root,
leaf
NCBI PubMed ID: 10193197Publication DOI: 10.1055/s-1999-13967Journal NLM ID: 0066751Publisher: George Thieme
Correspondence: Zhu M <minzhu
cuhk.edu.hk>
Institutions: Department of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China
Roots and leaves of Schefflera bodinieri were studied for their activity in the central nervous system (CNS) by bioassay-guided isolation in conjunction with receptor binding assays. As demonstrated in preliminary screening, ethanol extracts of leaves and roots of S. bodinieri showed strong binding affinity to a number of CNS receptors. Chemical investigation of this plant species was then conducted and fourteen plant ingredients were obtained. In this study, nine of these isolated compounds were tested by fifteen receptor binding assays for their CNS activities. Results showed that three compounds, namely bodinone, bodinone glycoside and D-sorbitol, were able to selectively bind to muscarine receptors, a trisaccharide bound to Ca2+ channel and 5HT-2 receptors, stigmasterol 3-O-glucoside bound to 5HT- 2 receptors, and bodirin A bound to dopamine-2 receptors with IC50 values at μM level. In the drug-interaction studies, bodinone, bodinone glycoside, bodirin A, bodinitin A and the trisaccharide were found to affect binding affinity of certain specific binding agents to the 5HT1C, 5HT2, opiate, β- adrenergic and histamine 1 receptors. These observations suggest interactions between the plant ingredients and receptors as well as synergistic effect of various compounds at receptor level.
interaction, araliaceae, Schefflera bodinieri, plant ingredients, receptor binding assay
Structure type: monomer
Location inside paper: compound 9, stigmasterol glucoside, p. 100 (bottom fig., 9)
Trivial name: stigmasterol 3-O-β-D-glucopyranoside
Compound class: saponin glycoside, glycoside, steroid glycoside, triterpenoid glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: NMR, HPLC, binding assays
Biological activity: Stigmasterol glucoside showed 5HT2 receptor binding activity with IC50 of 8.04±0.88 μM and Ki 3.45-4.32 μM.
Comments, role: structure is discussed in ref. [3-5]
Related record ID(s): 63097, 63098, 63099, 63100, 63101, 64157
NCBI Taxonomy refs (TaxIDs): 1433814
Show glycosyltransferases
There is only one chemically distinct structure:
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