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1. (Article ID: 6421)
Kuzmich A, Romanenko LA, Kokoulin MS
Cell-cycle arrest and mitochondria-dependent apoptosis induction in T-47D cells by the capsular polysaccharide from the marine bacterium Kangiella japonica KMM 3897
Carbohydrate Polymers 320 (2023)
121237
In this study, we reported the in vitro mechanisms of antiproliferative activity of capsular polysaccharide derived from marine Gram-negative bacteria Kangiella japonica KMM 3897 in human breast сarcinoma T-47D cells. Flow cytometric and Western blot analysis revealed that capsular polysaccharide effectively suppressed T-47D cell proliferation by inducing G0/G1 phase arrest and mitochondrial-dependent apoptosis. Moreover, polysaccharide influenced the ERK1/2 and p38 signaling pathways. The results of this study would enrich our understanding of the molecular mechanism of the anti-cancer activity of sulfated polysaccharides from marine Gram-negative bacteria.
Marine bacteria, apoptosis, sulfated polysaccharide, Kangiella japonica, T-47D, cell-cycle arrest
NCBI PubMed ID: 37659798Publication DOI: 10.1016/j.carbpol.2023.121237Journal NLM ID: 8307156Publisher: Elsevier
Correspondence: M.S. Kokoulin
mail.ru>
Institutions: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 159/2, Prospect 100 let Vladivostoku, Vladivostok 690022, Russia
Methods: 13C NMR, 1H NMR, GC-MS, SDS-PAGE, sugar analysis, DNA techniques, Western blotting, methanolysis, HPLC, HPSEC, extraction, fluorescence microscopy, flow cytometry analysis, cultivation, data analysis, apoptosis assay
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