Taxonomic group: bacteria / Actinobacteria
(Phylum: Actinobacteria)
NCBI PubMed ID: 31899242Publication DOI: 10.1016/j.ijbiomac.2019.12.227Journal NLM ID: 7909578Publisher: Butterworth-Heinemann
Correspondence: schwarzer
biomed.cas.cz; sabina.gorska
hirszfeld.pl
Institutions: Laboratory of Microbiome Immunobiology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland, Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Novy Hradek, Czech Republic
A variety of health benefits has been documented to be associated with the consumption of probiotic bacteria, namely bifidobacteria and lactobacilli. Thanks to the scientific advances in recent years we are beginning to understand the molecular mechanisms by which bacteria in general and probiotic bacteria in particular act as host physiology and immune system modulators. More recently, the focus has shifted from live bacteria towards bacteria-derived defined molecules, so called postbiotics. These molecules may represent safer alternative compared to the live bacteria while retaining the desired effects on the host. The excellent source of effector macromolecules is the bacterial envelope. It contains compounds that are pivotal in the adhesion phenomenon, provide direct bacteria-to-host signaling capacity and the associated physiological impact and immunomodulatory properties of bacteria. Here we comprehensively review the structure and biological role of Bifidobacterium surface and cell wall molecules: exopolysaccharides, cell wall polysaccharides, lipoteichoic acids, polar lipids, peptidoglycans and proteins. We discuss their involvement in direct signaling to the host cells and their described immunomodulatory effects.
exopolysaccharide, Bacterial antigens, Bifidobacterium, peptidoglycan, lipoteichoic acid, probiotics
Structure type: homopolymer ; n=22
Location inside paper: p.341, table 4
Compound class: cell wall polysaccharide
Contained glycoepitopes: IEDB_136044,IEDB_137472,IEDB_141794,IEDB_153201,IEDB_156489,IEDB_156493,IEDB_156557,IEDB_190606,SB_165,SB_166,SB_187,SB_195,SB_7,SB_88
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 1681Reference(s) to other database(s): GTC:G69386QK
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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