Natural polysaccharides have an important role in pharmaceutical industries and are considered a huge source and importance. Polysaccharides are biopolymers characterized by complex secondary structures performing several roles in plants, animals, and different other microorganisms. As it has versatility such as hydrophilicity, good stability, safety, lack of toxicity, and biodegradability in nature, some of them are extensively used for food packaging, pharmaceutical formulations, and various kind of sustainable and renewable goods in biomedical industries. In this context, we focused on natural polysaccharides from different sources such as plants, animals, algae, and microbes. Here, we concentrate on the chemical structures along with their commercial importance in the pharmaceutical industry. Moreover, a summary of the formulations and their applications in different natural polysaccharides has been highlighted in this review. Therefore, this study might be helpful for the development of not only different pharmaceutical formulations but also advantageous in food and biomedical industries in the future.

microbial polysaccharides, algal polysaccharides, bioactive polymer, natural polysaccharides, pharmaceutical formulation, plant polysaccharides

• Compound ID: 1721
  

  Pyr-(2-6:2-4)-b-D-Manp-(1-4)-b-D-GlcpA-(1-2)-a-D-Manp6Ac-(1-3)-+ | -4)-b-D-Glcp-(1-4)-b-D-Glcp-(1-

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  Structure type: polymer chemical repeating unit
  Trivial name: xanthan, xanthan gum
  Compound class: CPS, EPS
  Reference(s) to other database(s): GlycomeDB:17022
  
   
  
  Xanthomonas campestris
  CSDB ID 27053 (all data & tools)
• Compound ID: 16699
  

  Suc-(1-6)-+ | Pyr-(2-6:2-4)-b-D-Glcp-(1-3)-b-D-Glcp-(1-3)-b-D-Glcp-(1-6)-b-D-Glcp-(1-6)-b-D-Glcp-(1-4)-b-D-Glcp6Ac-(1-4)-b-D-Glcp-(1-3)-b-D-Galp

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  Structure type: structural motif or average structure
  Trivial name: succinoglycan
  Compound class: EPS
  
   
  
  Rhizobium, Pseudomonas, Sinorhizobium, Agrobacterium
  CSDB ID 27056 (all data & tools)
• Compound ID: 16697
  

  b-D-Fruf-(2-1)-+ | -6)-b-D-Fruf-(2-6)-b-D-Fruf-(2-

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  Structure type: structural motif or average structure
  Trivial name: levan
  Compound class: EPS
  
   
  
  Halomonas smyrnensis, Acinetobacter nectaris, Bacillus licheniformis, Bacillus atrophaeus, Bacillus polymyxa, Bacillus lentus, Lactobacillus sanfranciscensis, Microbacterium laevaniformans, Leuconostoc citreum, Zymomonas mobilis
  CSDB ID 27054 (all data & tools)
• Compound ID: 16698
  

  ?%GroA-(1-2)-+ | -3)-b-D-Glcp6(%)Ac-(1-4)-b-D-GlcpA-(1-4)-b-D-Glcp-(1-4)-a-L-Rhap-(1-

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  Structure type: structural motif or average structure
  Trivial name: gellan gum
  Compound class: EPS
  
   
  
  Pseudomonas elodea, Sphingomonas paucimobilis ATC 31461, Sphingomonas paucimobilis E2 (DSM 6314), Sphingomonas paucimobilis NK 2000
  CSDB ID 27055 (all data & tools)
• Compound ID: 16696
  

  /Variants 0/-+ | -6)-a-D-Glcp-(1- /Variants 0/ is: a-D-Glcp-(1-4)- OR (exclusively) a-D-Glcp-(1-3)- OR (exclusively) a-D-Glcp-(1-2)-

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  Structure type: fragment of a bigger structure
  Trivial name: dextran
  Compound class: EPS
  
   
  
  Leuconostoc, Weissella, Lactobacillus, Streptococcus, Pediococcus
  CSDB ID 27052 (all data & tools)
• Compound ID: 4415
  

  -3)-b-D-Glcp-(1-

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  Structure type: homopolymer
  Trivial name: glucan, β-1,3-glucan, curdlan, curdlan-type polysaccharide 13140, paramylon, curdlan, laminarin, β-glucan, curdlan, β-(1,3)-glucan, β-(1,3)-glucan, curdlan, curdlan, β-1,3-glucan, paramylon, reserve polysaccharide, b-glucan, β-1,3-D-glucan, laminaran, botryosphaeran, laminaran type β-D-glucan, latiglucan I, pachymaran, Curdlan, zymosan A, β-glucan, curdlan, laminarin, zymosan, zymosan, glucan particles, zymosan, β-(1-3)-glucan, β-(1,3)-glucan, β-(1,3)glucan, pachymaran, D-glucan (DPn)540, pachyman, laminaran, curdlan, zymosan, zymosan, β-(1,3)-glucan, zymosan A, zymosan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, pachyman, β-(1,3)-glucan, curdlan, callose, a water-insoluble β-(1→3)-glucan, fermentum β-polysaccharide, water-insoluble glucan, alkali-soluble β-glucan (PeA3), alkali-soluble polysaccharide (PCAP), callose, laminarin
  Compound class: EPS, O-polysaccharide, cell wall polysaccharide, lipophosphoglycan, glycoprotein, LPG, glucan, polysaccharide, glycoside, β-glucan, β3-glucan, cell wall glucan
  Reference(s) to other database(s): GTC:G51056AN, GlycomeDB:157, CCSD:50049, CBank-STR:4225, CA-RN: 51052-65-4, GenDB:FJ3380871.1
  
   
  
  Alcaligenes faecalis
  CSDB ID 22330 (all data & tools)