Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: aerial part
NCBI PubMed ID: 10736009Publication DOI: 10.1046/j.1472-765x.2000.00692.xJournal NLM ID: 8510094Institutions: Pharmaco-Biological Department, Microbiological Section, School of Pharmacy, University of Messina, Messina, Italy, Pharmaceutical Science Department, School of Pharmacy, University of Salerno, Salerno, Italy
The antimicrobial activity of a methanol extract and isolated constituents of Mitracarpus scaber, a species used in folk medicine by West African native people, was evaluated against Staphylococcus aureus and Candida albicans strains. The mitracarpus methanol extract possesses both antibacterial and antimycotic activities (minimum inhibitory concentration-MIC 31.25 and 62.50 μg/ml, respectively). This extract was subsequently fractioned and monitored by bioassays leading to the isolation of seven compounds screened for antibacterial and antimycotic activities. Among these compounds, gallic acid and 3,4,5-trimethoxybenzoic acid inhibited the growth of Staph. aureus (MIC 3.90 and 0.97 μg/ml). 4-Methoxyacetophenone and 3,4,5-trimethoxyacetophenone effectively inhibited C. albicans (MIC 1.95 μg/ml). The other compounds (kaempferol-3-O-rutinoside, rutin and psoralen) which were also isolated showed low antibacterial and antimycotic activities (125-500 μg/ml).
Staphylococcus aureus, Candida albicans, antimicrobial activity, Mitracarpus scaber, West African medicine
Structure type: oligomer
C
27H
30O
16Location inside paper: p. 106, Table 1, compound 6
Trivial name: rutin, rutoside, rutin, quercetin rutinoside, rutoside, quercetin 3-O-rutinose, quercetin-3-O-rutinoside, quercetin 3-O-rutinoside
Compound class: saponin glycoside, glycoside, flavonoid glycoside, flavonol glycoside, flavone glycoside
Contained glycoepitopes: IEDB_136105,IEDB_142488,IEDB_144144,IEDB_146664,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
Methods: TLC, extraction, CC, antibacterial assay, antifungal activity test
Related record ID(s): 64964
NCBI Taxonomy refs (TaxIDs): 60380Reference(s) to other database(s): CCSD:
50720, CBank-STR:3399
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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