Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
NCBI PubMed ID: 11054845Publication DOI: 10.1002/1099-1573(200011)14:7<538::aid-ptr631>3.0.co;2-1Journal NLM ID: 8904486Publisher: Chichester: Wiley
Correspondence: Capasso A <annacap
unisa.it>
Institutions: Dipartimento di Scienze Farmaceutiche, Università di Salerno, Salerno, Italy
The effects of extracts, partially purified fractions and four flavonol glycosides 1-4 from Aristeguietia discolor were investigated on the naloxone-precipitated withdrawal contraction of the acute morphine dependent guinea-pig ileum in vitro. After a 4 min in vitro exposure to morphine a strong contraction of guinea-pig isolated ileum was observed after the addition of naloxone. Both MeOH extract (50, 100 and 200 mg/mL), the partially purified fractions I, L, M and N (50, 100 and 200 mg/mL) and flavonol glycosides 1-4 (100, 50, 10 μM), injected 10 min before morphine, were capable of blocking the naloxone-induced contraction after exposure to morphine in a concentration-dependent fashion. The results of the present paper suggest that flavonol glycosides from Aristeguietia discolor may play an important role in the control of morphine withdrawal.
guinea-pig ileum, Aristeguietia discolor, morphine, naloxone
Structure type: oligomer
C
27H
30O
16Location inside paper: p. 538, structure 4
Trivial name: rutin, rutoside, rutin, quercetin rutinoside, rutoside, quercetin 3-O-rutinose, quercetin-3-O-rutinoside, quercetin 3-O-rutinoside
Compound class: saponin glycoside, glycoside, flavonoid glycoside, flavonol glycoside, flavone glycoside
Contained glycoepitopes: IEDB_136105,IEDB_142488,IEDB_144144,IEDB_146664,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
Methods: biological assays
Related record ID(s): 65004, 65005, 65006, 65008, 65009
NCBI Taxonomy refs (TaxIDs): 13516Reference(s) to other database(s): CCSD:
50720, CBank-STR:3399
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There is only one chemically distinct structure:
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(later renamed to: Eupatorium discolor)