Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: aerial part
NCBI PubMed ID: 10815006Publication DOI: 10.1002/(sici)1099-1573(200005)14:3<156::aid-ptr630>3.0.co;2-vJournal NLM ID: 8904486Publisher: Chichester: Wiley
Correspondence: Capasso A <annacap
unisa.it>
Institutions: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Salerno, Italy
The present study examines the effects of the extracts [petroleum ether, CHCl3, CHCl3/MeOH (9:1) and MeOH], partially purified fractions and pure compounds from Croton menthodorus on the electrically induced contractions of the isolated guinea-pig ileum (ECI). The results of the experiments indicate that CHCl(3)/MeOH (9:1) and MeOH extracts, tested at concentrations of 100, 50 and 25 μg/mL, dose-dependently reduced the guinea-pig ileum contractions, whereas petroleum ether and CHCl3 extracts did not affect it. Furthermore, the partially purified fractions III-VI from the CHCl3/MeOH extract, each tested at concentrations of 100, 50 and 25 μg/mL also inhibited ECI. Finally, pure compound 1 (6, 3, 1 μM) isolated and purified from the most active fraction III significantly reduced, in a dose-dependent manner, the electrical contractions of the ileum. Compound 1 was identified by NMR and EI-MS data as the morphinandien-7-one, O-methylflavinantine.
flavonol glycosides, guinea-pig ileum, Croton menthodorus, electrically induced contractions, O-methylflavinantine
Structure type: oligomer
Location inside paper: p. 158, Fig. 2, structure 7
Compound class: glycoside, flavonoid glycoside
Contained glycoepitopes: IEDB_116879,IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, TLC, biological assays, extraction, EI-MS, column chromatography, RP-HPLC
Related record ID(s): 65010, 65011, 65012
NCBI Taxonomy refs (TaxIDs): 1639638
Show glycosyltransferases
There is only one chemically distinct structure:
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