The β-1–6-linked poly-N-acetylglucosamine (PNAG) polymer is a conserved surface polysaccharide produced by many bacteria, fungi, and protozoan (and even filarial) parasites. This wide-ranging expression makes PNAG an attractive target for vaccine development, as it potentially encompasses a broad range of microorganisms. Significant progress has been made in discovering important properties of the biology of PNAG expression in recent years. The molecular characterization and regulation of operons for the production of PNAG biosynthetic proteins and enzymes have been studied in many bacteria. In addition, the physiological function of PNAG has been further elucidated. PNAG-based vaccines and PNAG-targeting antibodies have shown great efficacy in preclinical research. Furthermore, clinical tests for both vaccines and antibodies have been carried out in humans and economically important animals, and the results are promising. Although it is not destined to be a smooth road, we are optimistic about new vaccines and immunotherapeutics targeting PNAG becoming validated and eventually licensed for clinical use against multiple infectious agents

monoclonal antibody, conjugate vaccine, poly-N-acetylglucosamine

Publication DOI: 10.1016/j.eng.2023.09.012
Journal NLM ID: 101673395
Publisher: Beijing: Higher Education Press
Correspondence: gpierbwh.harvard.edu
Institutions: Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
 

• Compound ID: 1030
  

  -6)-b-D-GlcpNAc-(1-

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  Structure type: homopolymer
  Trivial name: poly-β-1,6-GlcNAc (PGA), biofilm, poly-b-(1-6)-N-acetyl-D-glucosamine (PNAG), poly-β-N-acetyl-glucosamine (PNAG), PNAG, poly-N-acetylglucosamine, PNAG
  Compound class: CPS, EPS, O-polysaccharide, glucan, polysaccharide
  Reference(s) to other database(s): GTC:G36952FI, GlycomeDB:11210
  
   
  
  Escherichia coli, Bordetella bronchiseptica, Streptococcus equi ssp. equi, Acinetobacter baumannii, Listeria monocytogenes, Streptococcus equi ssp. zooepidemicus, Shigella, Bordetella parapertussis, Actinobacillus pleuropneumoniae, Bordetella pertussis, Mycobacterium tuberculosis, Aggregatibacter actinomycetemcomitans, Yersinia pestis, Candida albicans, Babesia bovis, Klebsiella pneumoniae, Staphylococcus aureus, Babesia bigemina, Yersinia enterocolitica, Neisseria gonorrhoeae, Babesia divergens, Enterobacter cloacae, Staphylococcus epidermidis, Babesia microti, Yersinia pseudotuberculosis, Neisseria meningitidis, Enterococcus faecalis, Bacillus subtilis, Streptococcus pneumoniae, Streptomyces lividans, Trichomonas vaginalis, Vibrio parahemolyticus, Francisella tularensis, Plasmodium, Streptococcus pyogenes, Aspergillus fumigatus, Haemophilus ducreyi, Burkholderia cepacia, Aspergillus flavus, Bacteroides fragilis, Streptococcus agalactiae, Haemophilus influenzae, Stenotrophomonas maltophilia, Fusarium solani
  CSDB ID 15645 (all data & tools)