Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: seed
NCBI PubMed ID: 10640585Publication DOI: 10.1016/s0168-3659(99)00179-0Journal NLM ID: 8607908Publisher: Amsterdam: Elsevier Science Publishers
Correspondence: Rubinstein A <avri
cc.huji.ac.il>
Institutions: The Hebrew University of Jerusalem, Faculty of Medicine, School of Pharmacy, Jerusalem, Israel, Perio Products Ltd., Jerusalem, Israel, David R. Bloom Center for Pharmacy, Hebrew University, Jerusalem, Israel
Guar gum (GG) was crosslinked with increasing amounts of trisodium trimetaphosophate (STMP) to reduce its swelling properties for use as a vehicle in oral delivery formulations, especially drug delivery systems aimed at localizing drugs in the distal portions of the small bowel. Swelling of GG in artificial gastrointestinal fluids was reduced from 100 to 120-fold (native GG) to 10-35-fold depending on the amount of crosslinker used, showing a bell-shape dependency. As a result of the crosslinking procedure GG lost its non-ionic nature and became negatively charged. This was demonstrated by methylene blue (MB) adsorption studies and swelling studies in sodium chloride solutions with increasing concentrations in which the hydrogels' network collapsed. The adsorption of MB was also used to characterize the degree of the GG crosslinking, from which the effective network density was calculated. In addition, effective network density was calculated from elasticity measurements. Both measurements showed that the crosslinking density (but not swelling) of the new products was linearly dependent on the amount of STMP used in the reaction.
crosslinking, guar gum, trisodium trimetaphosophate, crosslinking density, methylene blue
Structure type: structural motif or average structure ; n=1000-1500
Location inside paper: p. 122, Scheme 1, A
Trivial name: guar gum
Compound class: polysaccharide, galactomannan
Contained glycoepitopes: IEDB_136906,IEDB_137472,IEDB_137485,IEDB_140116,IEDB_141794,IEDB_144983,IEDB_151528,IEDB_152206,IEDB_190606,IEDB_76920,IEDB_983930,SB_44,SB_7,SB_72
Methods: binding assays, derivatization, swelling measurement
NCBI Taxonomy refs (TaxIDs): 3832
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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