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Guyanchandani A, Khan ZK, Maitra SC
Arbortristosides modulate murine peritoneal macrophages for phagocytosis and intracellular killing of Candida albicans
Pharmaceutical Biology 38(5) (2000)
340-352
|
pCoum4Me-(9-7)-+
|
b-D-Glcp-(1-1)-Subst
Subst = arbortristoside A, C aglycon = SMILES C[C@@H]1[C@@H]2[C@@H](C(C(OC)=O)=CO{1}[C@H]2O){6}[C@H](O){7}[C@@H]1O |
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Nyctanthes arbor-tristis
(NCBI TaxID 41398,
species name lookup)
Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: seed
Publication DOI: 10.1076/phbi.38.5.340.5969Journal NLM ID: 9812552Publisher: Lisse, the Netherlands: Swets & Zeitlinger
Correspondence: Khan ZK <root
cscdri.ren.nic.in>
Institutions: Division of Medical Mycology, Central Drug Research Institute, Lucknow, India, Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India
Studies indicate that arbortristoside C (50 µg/ml)-primed murine peritoneal macrophages (MuPMØs) provide high phagocytosis (85%) in a concentration-dependent manner at a target: effector ratio of 1:5, with an optimal Phagocytic Index (PI) of 8.2 at 6 hr, compared to arbortristoside A or control. Recombinant murine interferon gamma (rMuIFN-γ)-primed MuPMØ, at 100 U, provided 98% phagocytosis with a PI 8.5 at 24 hr. The intracellular killing of C. albicans in arbortristoside C-primed MuPMØ was enhanced to 10% at 1 hr, and 25% at 3 hr, compared to control. The rMuIFN-γ-primed MuPMØ, at 100 U, yielded 50% killing of blastospores at 3 hr, compared to 10 U of rMuIFN-γ which was less detrimental (45%) in a concentration- and time-dependent manner. The intracellular residence of blastospores beyond 3 hr caused rupturing and killing of MuPMØs due to extensive germ tube formation. Transmission electron microscopic evidence further indicates arbortristoside C-primed MuPMØ activated lysosomal machinery causes fusion of phagolysosome with digested blastospores.
yeast, transmission electron microscopy (TEM), arbortristosides, immune modulation, MuPMØs
Structure type: monomer
Trivial name: arbortristoside A
Compound class: glycoside, iridoid glycoside
Contained glycoepitopes: IEDB_116879,IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: biological assays, microscopy, cell viability assay, TEM, centrifugation, antifungal activity test, phagocytosis assay, immunomodulatory activity analysis, cell density determination
Related record ID(s): 65674
NCBI Taxonomy refs (TaxIDs): 41398
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Guyanchandani A, Khan ZK, Maitra SC
Arbortristosides modulate murine peritoneal macrophages for phagocytosis and intracellular killing of Candida albicans
Pharmaceutical Biology 38(5) (2000)
340-352
|
pCoum-(9-7)-+
|
b-D-Glcp-(1-1)-Subst
Subst = arbortristoside A, C aglycon = SMILES C[C@@H]1[C@@H]2[C@@H](C(C(OC)=O)=CO{1}[C@H]2O){6}[C@H](O){7}[C@@H]1O |
Show graphically |
Nyctanthes arbor-tristis
(NCBI TaxID 41398,
species name lookup)
Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: seed
Publication DOI: 10.1076/phbi.38.5.340.5969Journal NLM ID: 9812552Publisher: Lisse, the Netherlands: Swets & Zeitlinger
Correspondence: Khan ZK <root
cscdri.ren.nic.in>
Institutions: Division of Medical Mycology, Central Drug Research Institute, Lucknow, India, Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India
Studies indicate that arbortristoside C (50 µg/ml)-primed murine peritoneal macrophages (MuPMØs) provide high phagocytosis (85%) in a concentration-dependent manner at a target: effector ratio of 1:5, with an optimal Phagocytic Index (PI) of 8.2 at 6 hr, compared to arbortristoside A or control. Recombinant murine interferon gamma (rMuIFN-γ)-primed MuPMØ, at 100 U, provided 98% phagocytosis with a PI 8.5 at 24 hr. The intracellular killing of C. albicans in arbortristoside C-primed MuPMØ was enhanced to 10% at 1 hr, and 25% at 3 hr, compared to control. The rMuIFN-γ-primed MuPMØ, at 100 U, yielded 50% killing of blastospores at 3 hr, compared to 10 U of rMuIFN-γ which was less detrimental (45%) in a concentration- and time-dependent manner. The intracellular residence of blastospores beyond 3 hr caused rupturing and killing of MuPMØs due to extensive germ tube formation. Transmission electron microscopic evidence further indicates arbortristoside C-primed MuPMØ activated lysosomal machinery causes fusion of phagolysosome with digested blastospores.
yeast, transmission electron microscopy (TEM), arbortristosides, immune modulation, MuPMØs
Structure type: monomer
Trivial name: arbortristoside C
Compound class: glycoside, iridoid glycoside
Contained glycoepitopes: IEDB_116879,IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: biological assays, microscopy, cell viability assay, TEM, centrifugation, antifungal activity test, phagocytosis assay, immunomodulatory activity analysis, cell density determination
Related record ID(s): 65673
NCBI Taxonomy refs (TaxIDs): 41398
Show glycosyltransferases
There is only one chemically distinct structure:
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