Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Pasteurella multocida [ICD11:
XN30D 
]
NCBI PubMed ID: 12350324Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: paul-deangelis
ouhsc.edu
Institutions: Department of Biochemistry and Molecular Biology, Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Pasteurella multocida is a pathogenic Gram-negative bacterial species that infects a wide variety of animals and humans. A notable morphological feature of many isolates is the extracellular capsule. The ability to remove the capsule by treatment with certain glycosidases has been utilized to discern various capsular types called A, D and F. Based on this preliminary evidence, these microbes have capsules made of glycosaminoglycans, linear polysaccharides composed of repeating disaccharide units containing an amino sugar. Glycosaminoglycans are also abundant components of the vertebrate extracellular matrix. It has been shown previously that the major Type A capsular material was hyaluronan (hyaluronic acid). We report that the Type D polymer is an unmodified heparin (N-acetylheparosan) with a →4)-β-D-Glcp-UA-(1→4)-α-D-Glcp-NAc-(1→ repeating unit and the Type F polymer is an unmodified chondroitin with a →4)-β-D-Glcp-UA-(1→3)-β-D-Galp-NAc-(1→ repeating unit. The monosaccharide compositions, disaccharide profiles, and 1H NMR analyses are consistent with these identifications. The molecular size of the Pasteurella polymers is approximately 100-300 kDa as determined by gel electrophoresis and multi-angle laser light scattering; this size is much greater than the 10-30 kDa size of the analogous polymers isolated from animal tissues. The glycosaminoglycan capsular polymers are relatively non-immunogenic virulence factors that enhance microbial pathogenicity.
capsular polysaccharide, chondroitin, glycosaminoglycan, Pasteurella multocida, Heparosan
Structure type: polymer chemical repeating unit
Location inside paper: Abstract
Trivial name: K5 polysaccharide, K-antigen, N-acetyl heparosan, heparosan (N-acetylheparosan), heparosan, heparosan (glycosaminoglycan GAG), K5 CPS, heparosan (K5-antigen), N-acetylheparosan
Compound class: EPS, K-antigen, CPS, polysaccharide
Contained glycoepitopes: IEDB_115136,IEDB_140630,IEDB_141807,IEDB_151531,IEDB_153764,IEDB_423153
Related record ID(s): 6606
NCBI Taxonomy refs (TaxIDs): 747Reference(s) to other database(s): GTC:G26089XS, GlycomeDB:
656
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There is only one chemically distinct structure:
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