Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
NCBI PubMed ID: 10901280Publication DOI: 10.1016/s0024-3205(00)00608-1Journal NLM ID: 0375521Publisher: Amsterdam: Elsevier
Institutions: College of Pharmacy, Seoul National University, Seoul, South Korea, Dong-A Pharmaceutical Company Ltd., Kyunggi-Do, South Korea
The extract of Crataegus, a mixture of flavonoids and procyanidins extracted from hawthorn, Crataegus oxyacantha, L. and C. monogyna Jacq., relaxed vascular tone or increased production of cyclic GMP in the rat aorta, but flavonoid components of Crataegus extract, hyperoside, rutin and vitexin, did not affect the vascular tone. The aim of the present study was to characterize the endothelium-dependent relaxation elicited by procyanidins fractionated from Crataegus extract in isolated rat aorta. Procyanidins caused endothelium-dependent relaxation which was associated with the production of cyclic GMP. Both responses to these procyanidins were inhibited by methylene blue or N(G)-nitro-L-arginine, but not by indomethacin. Relaxation in response to procyanidins was not affected by atropine, diphenhydramine, [D-Pro2,D-Trp7,9]substance P, propranolol, nifedipine, verapamil and glibenclamide, but were markedly reduced by tetraethylammonium. These findings showed that procyanidins in Crataegus extract may be responsible for the endothelium-dependent nitric oxide-mediated relaxation in isolated rat aorta, possibly via activation of tetraethylammonium-sensitive K+ channels.
nitric oxide, procyanidins, aorta, vascular relaxation, cyclic GMP, K+ channels
Structure type: oligomer
C
27H
30O
16Location inside paper: p. 127, Fig. 4,
Trivial name: rutin, rutoside, rutin, quercetin rutinoside, rutoside, quercetin 3-O-rutinose, quercetin-3-O-rutinoside, quercetin 3-O-rutinoside
Compound class: saponin glycoside, glycoside, flavonoid glycoside, flavonol glycoside, flavone glycoside
Contained glycoepitopes: IEDB_136105,IEDB_142488,IEDB_144144,IEDB_146664,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
Methods: acid hydrolysis, biological assays, UV, CC, centrifugation
Related record ID(s): 65984, 65986
NCBI Taxonomy refs (TaxIDs): 510738,
140997Reference(s) to other database(s): CCSD:
50720, CBank-STR:3399
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There is only one chemically distinct structure:
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(later renamed to: Crataegus rhipidophylla)