Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: root
NCBI PubMed ID: 10865449Publication DOI: 10.1055/s-2000-8540Journal NLM ID: 0066751Publisher: George Thieme
Correspondence: lclin
cma23.nricm.edu.tw
Institutions: National Research Institute of Chinese Medicine, Taipei, Taiwan, China
From the root of Limonium sinense (Girard) Ktze a new (2R,3S)-3,5,7,4′-tetrahydroxy-3′,5′-dimethoxyflavanone was isolated and named isodihydrosyringetin (3), together with nine other known compounds, (-)-epigallocatechin 3-O-gallate (1), samarangenin B (2), myricetin (4), myricetin 3-O-α-rhamnopyranoside (5), quercetin 3-O-α-rhamnopyranoside (6), (-)-epigallocatechin (7), gallic acid (8), N-trans-caffeoyltyramine (9), and N-trans-feruloyltyramine (10). All of them were examined for their inhibitory effects on herpes simplex virus type-1 (HSV-1) replication in Vero cells. Both compounds 1 and 2 exhibited potent inhibitory activities in HSV-1 replication. Comparison of the IC50 values indicated that compounds 1 and 2 had higher inhibitory activities than the positive control acyclovir (38.6 ± 2.6 vs. 55.4 ± 5.3 μM, P < 0.001; 11.4 ± 0.9 vs. 55.4 ± 5.3 μM, P < 0.0005). Cytotoxicity was unlikely involved because no cell deaths were observable in the Vero cells following 5 day treatments with compound 1 or 2.
inhibition, Limonium sinense, Plumbaginaceae, isodihydrosyringetin, herpes simplex virus type-1
Structure type: monomer
C
21H
20O
12Location inside paper: p. 335, left column, paragraph 1, 5
Trivial name: myricitrin
Compound class: glycoside, flavonoid glycoside, flavonol glycoside
Contained glycoepitopes: IEDB_136105,IEDB_225177,IEDB_885823
Methods: 13C NMR, 1H NMR, NMR-2D, TLC, ESI-MS, acid hydrolysis, biological assays, HPLC, alkaline hydrolysis, extraction, CI-MS, HR-ESI-MS, cytotoxicity assay, evaporation, centrifugation
Related record ID(s): 66506
NCBI Taxonomy refs (TaxIDs): 293752Reference(s) to other database(s): CCSD:
49968, CBank-STR:384
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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