Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
NCBI PubMed ID: 11201296Publication DOI: 10.1515/dmdi.2000.17.1-4.211Journal NLM ID: 8904736Publisher: Berlin: De Gruyter
Correspondence: v.rao
utoronto.ca
Institutions: Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Triterpenoid and steroidal glycosides, referred to collectively as saponins, are bioactive compounds present naturally in many plants. They have considerable potential as pharmaceutical and/or nutraceutical agents in natural or synthetic form. Saponins, from a variety of sources, have been shown to have hypocholesterolemic, anticoagulant, anticarcinogenic, hepatoprotective, hypoglycemic, immunomodulatory, neuroprotective, anti-inflammatory and anti-oxidant activity. This paper reviews saponin research of the last decade, focussing on developments in understanding their mechanism of action and structure-activity relationships. Virtually all of this work has used animal and in vitro models. To date there are very few human data.
immunomodulation, hypoglycemic activity, antiinflammatory activity, anti-oxidant activity, Hepatoprotection, steroidal glycosides, saponins, neuroprotection, triterpenoid glycosides, hypocholesterolemic activity, anti-coagulation, anticarcinogen
Structure type: monomer
Location inside paper: p. 216, ginsenoside Rh2
Trivial name: ginsenoside Rh2, (20S)-ginsenoside Rh2, ginsenoside
Compound class: saponin glycoside, glycoside, triterpene glycoside, triterpenoid glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Biological activity: compound inhibited the growth of human ovarian cancer in nude mice. Compound inhibited cellular proliferation in NIH 3T3 fibroblasts. This was due to the inhibitory effects of the saponins on phospholipase C which in turn reduced intracellular protein kinase C activity 1561. compound induced differentiation in F9 teratocarcinoma cells by increasing the nuclear translocation of glucocorticoid receptor, being structurally similar to glucocorticoid hormone. Compound induced apoptosis in SK-HEP-1 cells and C6 gliomal cell line 1661, in both cases by a capase-dependent but Bcl-2 and BC1-XL 1661 insensitive mechanism
Related record ID(s): 67380, 67381, 67382, 67383, 67384, 67385, 67386, 67387, 67389, 67390, 67391, 67392, 67393, 67394, 67395, 67396, 67397, 67398, 67399, 67400, 67401, 67402, 67403, 67404, 67405, 67406, 67407, 67408, 67409, 67410, 67411, 67412, 67413, 67414, 67415, 67416, 67417, 67418, 67419, 67420, 67421
NCBI Taxonomy refs (TaxIDs): 4054
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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