The use of a novel monoclonal antibody (mAb) that reacts with (1,6)-β-glucan has permitted the study of the different covalent linkages between glucan and mannoproteins in the cell wall of Candida albicans. The mAb JRR1 was originally raised by immunization with Zymolyase extracts from C. albicans cell walls, but it soon became apparent that it reacted with a (1,6)-β-glucan epitope. By using this antibody, we show the existence of glucan-mannoprotein complexes between the (1,6)-β-glucan epitope recognized by the antibody and cell wall mannoproteins. The topology of the (1,6)-β-glucan in the cell wall of C. albicans has also been studied.

• Compound ID: 6167
  

  -6)-b-D-Glcp-(1-

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  Structure type: homopolymer
  Trivial name: pustulan, β-1,6-glucan, β-1,6-D-glucan, β(1-6)-D-glucan, β-(1,6)-glucan, lasiodiplodan, pustulan, β-(1,6)-glucan, lasiodiplodan, β-(1,6)-glucan, β-(1,6)-glucan, lasiodiplodan, pustulan, β-1,6-glucan, β-(1,6)-glucan, pustulan, β-(1→6)-glucan PCPS, water-soluble glucan (PS-I)
  Compound class: EPS, O-polysaccharide, cell wall polysaccharide, glycoprotein, glucan, polysaccharide, cell wall glucoprotein
  Reference(s) to other database(s): GTC:G26777BZ, GlycomeDB:863, CCSD:50854, CBank-STR:4234
  
   
  
  Candida albicans
  CSDB ID 143682 (all data & tools)