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1. (Article ID: 6747)
 
Lester RL, Dickson RC
Sphingolipids with inositolphosphate-containing head groups
Advances in Lipid Research 26 (1993) 253-274
 

InsPCers have been characterized in many plants, fungi, and protozoans but not in animals. There are no well-documented reports of the absence of InsPCers in organisms of these categories and one might possibly consider these lipids to be ubiquitous in plants, fungi, and protozoans. The polar headgroups of these lipids display quite heterogeneous structures depending on the source, including attachment to proteins as possible membrane anchors. The ceramides are with some exceptions composed of phytosphingosine and a very long-chain, usually hydroxylated, fatty acid. The vital nature of such sphingolipids in the plasma membrane is indicated in S. cerevisiae. Clearly, much remains to be discovered about the structure, metabolism, and function of the InsPCers.

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2. (Article ID: 6822)
 
Barr K, Laine RA, Lester RL
Carbohydrate structures of three novel phosphoinositol-containing sphingolipids from the yeast Histoplasma capsulatum
Biochemistry 23 (1984) 5589-5596
 

From the yeast phase of the human pathogen Histoplasma capsulatum, three novel glycolipids were isolated, shown to react with sera from histoplasmosis patients, and partially characterized: compound V, ceramide-P-inositol-[mannose2]; compound VI, ceramide-P-inositol-[mannose2, galactose]; compound VIII, an isomer of compound VI [Barr, K., & Lester, R.L. (1984) Biochemistry (preceding paper in this issue)]. Ammonolysis of these lipids has yielded all the carbohydrate (oligosaccharides V, VI, and VIII) as novel, intact oligosaccharides suitable for characterization. Anomeric configurations were determined by specific glycosidase digestion and by the stability of peracetylated saccharides to CrO3 oxidation. Linkages were established by methylation analysis. These experiments yielded the following structural assignments: (formula; see text) The occurrence of galactofuranose is novel for glycosphingolipids, and it is noteworthy that compound VI is immunoreactive.

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