Found 1 publication. Displayed publication 1
Expand all publications       Show all as text (SweetDB notation)
1. (Article ID: 711)
 
Kaca W, Amano K, Chernyak AY, Knirel YA
Human anti-scrub typhus rickettsia antibodies and rabbit anti-Proteus antibodies recognize similar epitopes in the O-polysaccharide part of Proteus mirabilis OXK lipopolysaccharide
Microbios 130 (2000) 151-161
 

In the Weil-Felix test, sera from patients infected with Orientia tsutsugamushi reacted with lipopolysaccharide (LPS) from Proteus mirabilis OXK strains. The O-polysaccharide of P. mirabilis OXK LPS consisted of pentasaccharide repeating units, with amidically-linked lysine residues. The lysine, linked to galacturonic residues, which plays an important role in the reaction with rabbit anti-OXK antibodies, was revealed with the aid of synthetic antigens. Using ELISA, immunoglobulin M antibodies from scrub typhus patients reacted with the O-specific polysaccharide of strain OXK LPS only. This reaction was inhibited by rabbit antibodies specific to the O-antigen of strain OXK LPS. Both human and rabbit antibodies may bind to similar epitopes on the O-polysaccharide part of P. mirabilis OXK LPS.

Lipopolysaccharide, LPS, human, structural, characterization, O-antigen, antibodies, antibody, epitope, epitopes, O-polysaccharide, O polysaccharide, Proteus, Proteus mirabilis, serological, immunochemical, comparison, reaction, cross-reactive, cross-reaction, 2-acetamido-2-deoxy-D-glucose, rabbit, Weil-Felix test, Orientia tsutsugamushi, rickettsia

The publication contains the following compound(s):
 

Expand this publication

Resort publications by:

New query Export IDs Home Help

Execution: <1 sec