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1. (Article ID: 7121)
 
Simenel C, Coddeville B, Delepierre M, Latge JP, Fontaine T
Glycosylinositolphosphoceramides in Aspergillus Fumigatus
Glycobiology 18(1) (2008) 84-96
 

Fungal glycosylinositolphosphoceramides (GIPCs) are involved in cell growth and fungal–host interactions. In this study, six GIPCs from the mycelium of the human pathogen Aspergillus fumigatus were purified and characterized using Q-TOF mass spectrometry and 1H, 13C, and 31P NMR. All structures have the same inositolphosphoceramide moiety with the presence of a C18:0-phytosphingosine conjugated to a 2-hydroxylated saturated fatty acid (2-hydroxy-lignoceric acid). The carbohydrate moiety defines two types of GIPC. The first, a mannosylated zwitterionic glycosphingolipid contains a glucosamine residue linked in α1-2 to an inositol ring that has been described in only two other fungal pathogens. The second type of GIPC presents an α-Manp-(1→3)-α-Manp-(1→2)-IPC common core. A galactofuranose residue is found in four GIPC structures, mainly at the terminal position via a β1-2 linkage. Interestingly, this galactofuranose residue could be substituted by a choline–phosphate group, as observed only in the GIPC of Acremonium sp., a plant pathogen.

NMR, galactofuranose, glycosphingolipid, Aspergillus fumigatus, glycosylinositolphosphoceramide

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