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1. (Article ID: 7324)
 
Matei E, Louis JM, Jee J, Gronenborn AM
NMR solution structure of a cyanovirin homolog from wheat head blight fungus
Proteins 79(5) (2011) 1538-1549
 

Members of the cyanovirin-N homolog (CVNH) lectin family are found in bacteria, fungi and plants. As part of our ongoing work on CVNH structure-function studies, we determined the high-resolution NMR solution structure of the homolog from the wheat head blight disease causing ascomycetous fungus Gibberella zeae (or Fusarium graminearum), hereafter called GzCVNH. Like cyanovirin-N (CV-N), GzCVNH comprises two tandem sequence repeats and the protein sequence exhibits 30% identity with CV-N. The overall structure is similar to those of other members of the CVNH family, with the conserved pseudo-symmetric halves of the structure, domains A and B, closely resembling recently determined structures of Tuber borchii, Neurospora crassa, and Ceratopteris richardii CVNH proteins. Although GzCVNH exhibits a similar glycan recognition profile to CV-N and specifically binds to ManĪ±(1-2)ManĪ±, its weak carbohydrate binding affinity to only one binding site is insufficient for conferring anti-HIV activity.

lectin, NMR solution structure, CVNH, antiviral protein, HIV

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