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1. (Article ID: 7327)
 
Tada R, Yoshikawa M, Ikeda F, Adachi Y, Kato Y, Kuge T, Tanioka A, Ishibashi K, Tsubaki K, Ohno N
Induction of IFN-γ by a highly branched 1,3-β-D-glucan from Aureobasidium pullulans in mouse-derived splenocytes via dectin-1-independent pathways.
Biochemical and Biophysical Research Communications 404(4) (2011) 1105-1110
 

We have previously elucidated the precise structure of a unique type of 1,3-β-D-glucan, AP-FBG (Aureobasidium pullulans-fermented β-D-glucan), from the fungus A. pullulans and found that AP-FBG strongly induced the production of various cytokines in DBA/2 mouse-derived splenocytes in vitro. However, the mechanism(s) of action of AP-FBG on in vitro mouse primary cells have not been characterized in detail. Herein, we report that the production of IFN-γ in DBA/2 mouse-derived splenocytes by AP-FBG was not inhibited following treatment with an anti-dectin-1 neutralizing antibody. In addition, AP-FBG not only failed to activate dectin-1-mediated signaling pathways, examined by a reporter gene assay but also failed to bind to dectin-1, a pivotal receptor for 1,3-β-D-glucan. Taken together, AP-FBG induced cell activation via dectin-1-independent pathways.

structure, Aureobasidium pullulans, Dectin-1, b-D-Glucan, DBA/2 mice

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