Found 1 structure.
Displayed structure 1
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1. Compound ID: 7387
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a-Neup5Ac-(2-8)-a-Neup5Ac-(2-3)-b-D-Galp-(1-4)-b-D-Glcp-(1--/(1->4) core Hep I/ |
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Structure type: fragment of a bigger structure
Aglycon: (1->4) core Hep I
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130676,IEDB_130679,IEDB_136044,IEDB_136794,IEDB_137472,IEDB_141794,IEDB_142487,IEDB_142488,IEDB_146100,IEDB_146664,IEDB_149174,IEDB_150933,IEDB_150937,IEDB_153198,IEDB_153199,IEDB_190606,IEDB_858580,IEDB_983931,SB_116,SB_165,SB_166,SB_170,SB_171,SB_172,SB_187,SB_192,SB_195,SB_35,SB_37,SB_39,SB_42,SB_6,SB_68,SB_7,SB_76,SB_84,SB_88
The structure is contained in the following publication(s):
- Article ID: 3345
Schweda EK, Richards JC, Hood DW, Moxon ER "Expression and structural diversity of the lipopolysaccharide of Haemophilus influenzae: implication in virulence" -
International Journal of Medical Microbiology 297(5) (2007) 297-306
Lipopolysaccharide (LPS) is a major virulence determinant of the human bacterial pathogen Haemophilus influenzae. A characteristic feature of H. influenzae LPS is the extensive intra- and inter-strain heterogeneity of glycoform structure which is key to the role of the molecule in both commensal and disease-causing behaviour of the bacterium. Through the combination of genetics and detailed structural analyses, H. influenzae is an exemplar Gram-negative bacterium for which now the most extensive and detailed LPS structural data and functional correlates are available. LPS from H. influenzae consists of a conserved glucose-substituted triheptosyl inner-core moiety L-α-D-Hepp-(1→2)-[PEtn→6]-L-α-D-Hepp-(1→3)-[β-D-Glcp-(1→4)]-L-α-D-Hepp linked to lipid A via Kdo 4-phosphate. The inner-core unit provides the template for attachment of oligosaccharide- and non-carbohydrate substituents. Here, the structure, genetics and expression of LPS glycoforms in the outer core are reviewed as well as their implication on virulence
Lipopolysaccharide, Haemophilus influenzae, molecular mimicry, Phosphocholine, sialic acid, Digalactoside
NCBI PubMed ID: 17452015Publication DOI: 10.1016/j.ijmm.2007.03.007Journal NLM ID: 100898849Publisher: Jena, Germany: Urban & Fischer Verlag
Correspondence: elke.schweda@crc.ki.se
Institutions: Clinical Research Centre, Karolinska Institutet and University College of South Stockholm, NOVUM, S-141 86 Huddinge, Sweden
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