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1. (Article ID: 7392)
 
Smiderle FR, Olsen LM, Carbonero ER, Marcon R, Baggio CH, Freitas CS, Santos AR, Torri G, Gorin PA, Iacomini M
A 3-O-methylated mannogalactan from Pleurotus pulmonarius: Structure and antinociceptive effect
Phytochemistry 69(15) (2008) 2731-2736
 

A polysaccharide (Mw 23900 g/mol) was extracted with cold water from the basidiomycete Pleurotus pulmonarius, and its antinociceptive and anti-inflammatory properties were evaluated. It was a mannogalactan (MG), whose structure was characterized using mono- and two-dimensional NMR spectroscopy, methylation analysis, and a controlled Smith degradation. It had a main chain of (1→6)-linked α-d-galactopyranosyl and 3-O-methyl-α-d-galactopyranosyl units, both of which are partially substituted at O-2 by β-D-mannopyranosyl non-reducing ends. The MG was tested for its effects on the acetic acid-induced writhing reaction in mice, a typical model for inflammatory pain, causing a marked and dose-dependent inhibition of the nociceptive response, with ID50 of 16.2 (14.7-17.7) mg/kg and inhibition of 93 ± 3% at a dose of 30 mg/kg. An inflammatory response was not inhibited.

polysaccharide, Basidiomycete, mannogalactan, Pleurotus pulmonarius, antinociceptive effect

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