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1. (Article ID: 7490)
 
Inokoshi J, Takagi Y, Uchida R, Masuma R, Omura S, Tomoda H
Production of a new type of amidepsine with a sugar moiety by static fermentation of Humicola sp. FO-2942
The Journal of Antibiotics 63(1) (2010) 9-16
 

Static fermentation of amidepsine-producing fungus Humicola sp. FO-2942 led to the production of six new amidepsines, including a new type of glycosylated congener. Non-glycosylated amidepsine J inhibited both human diacylglycerol acyltransferases 1 (DGAT1) and DGAT2 with the same IC50 value of 40 μM, whereas glycosylated amidepsines F to I howed very weak inhibitory activity against DGAT1 and DGAT2

diacylglycerol acyltransferase, amidepsine, fungal metabolite, Humicola sp

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