Fungi are a fascinating group of predominantly multicellular organisms. Fungal species, such as Saccharomyces cerevisiae, have been instrumental in defining the fundamental processes of glycosylation, but their glycobiology is significantly different from animal or plant systems. This chapter describes the glycan structures that compose the fungal cell wall, offers some insights into novel glycobiology revealed through studying fungal systems, addresses the use of fungi as experimental and synthetic systems, and delineates the relationships of several important glycoconjugates to fungal biology and pathogenesis.
NCBI PubMed ID: 28876853Publication DOI: 10.1101/glycobiology.3e.023WWW link: https://www.ncbi.nlm.nih.gov/books/NBK453054/Publisher: Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press
Editors: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger RH
Institutions: Complex Carbohydrate Research Center, University of Georgia, Athens, USA, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan, Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, USA, National Center for Functional Glycomics, Harvard Medical School, Cambridge, USA, Glycobiology Research and Training Center, University of California, San Diego, USA, Albert Einstein College of Medicine, New York, NY, USA, Johns Hopkins University, Baltimore, USA, ETH Zürich, Zürich, Switzerland, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia, University of Georgia, Athens, Georgia, USA, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany
- Compound ID: 19301
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b-D-Manp-(1-2)-b-D-Manp-(1-2)-b-D-Manp-(1-2)-a-D-Manp-(1--P--?)--Subst
Subst = α-1,6-mannan backbone |
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Structure type: fragment of a bigger structure
Compound class: mannan, mannoprotein
- Compound ID: 19305
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a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: mannan, mannoprotein, O-linked glycoprotein
Reference(s) to other database(s): GTC:G25559RS
- Compound ID: 19314
Structure type: monomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G61491DK
- Compound ID: 19315
Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G81067HW
- Compound ID: 19316
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a-D-Galp-(1-6)-b-D-Galp-(1-?)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G85971MD
- Compound ID: 19317
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a-D-Galp-(1-6)-{{{-a-D-Galp-(1-6)-}}}/n=8/-a-D-Galp-(1-6)-b-D-Galp-(1-?)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G83450FK
- Compound ID: 19318
Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: mannan, mannoprotein, O-linked glycoprotein
Reference(s) to other database(s): GTC:G53402KW
- Compound ID: 19319
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b-D-Xylp-(1-?)-+
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a-D-Manp-(1-2)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G26839NK
- Compound ID: 19320
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b-D-Xylp-(1-?)-+
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a-D-Manp-(1-6)-a-D-Manp-(1-?)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G86280QB
- Compound ID: 19321
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b-D-Xylp-(1-?)-+
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a-D-Manp-(1-2)-a-D-Manp-(1-6)-a-D-Manp-(1-2)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G73751HQ
- Compound ID: 19002
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a-D-Manp-(1-3)-a-D-Manp-(1-3)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-polysaccharide, mannan, mannoprotein, O-linked glycoprotein
Reference(s) to other database(s): GTC:G44953KX
- Compound ID: 19300
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a-D-Manp-(1-3)-+
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a-D-Manp-(1-3)-a-D-Manp-(1-2)-a-D-Manp-(1-6)-a-D-Manp-(1-6)-+
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a-D-Manp-(1-3)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-+ |
| |
a-D-Manp-(1-3)-a-D-Manp-(1-2)-+ | |
| | |
a-D-Manp-(1-3)-a-D-Manp-(1--P--6)--a-D-Manp-(1-2)-+ | |
| | |
a-D-Manp-(1-3)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-+ | | |
| | | |
a-D-Manp-(1-3)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-+ | | | |
| | | | |
a-D-Manp-(1-3)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-+ | | | | |
| | | | | |
a-D-Manp-(1-6)-{{{-a-D-Manp-(1-6)-a-D-Manp-(1-6)-a-D-Manp-(1-6)-a-D-Manp-(1-6)-}}}a-D-Manp-(1-6)-a-D-Manp-(1-3)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-b-D-GlcpNAc1N-(1-4)-L-Asn-(?--/protein/ |
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Structure type: oligomer
Aglycon: protein
Compound class: N-glycan, mannoprotein
- Compound ID: 19322
Structure type: monomer
Aglycon: (->1) dolichol
- Compound ID: 19323
Structure type: oligomer
Aglycon: (->1) dolichol
- Compound ID: 19324
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b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1---P---P----/(->1) dolichol/ |
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Structure type: oligomer
Aglycon: (->1) dolichol
- Compound ID: 19325
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a-D-Manp-(1-3)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1---P---P----/(->1) dolichol/ |
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Structure type: oligomer
Aglycon: (->1) dolichol
- Compound ID: 19326
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a-D-Manp-(1-6)-+
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a-D-Manp-(1-3)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1---P---P----/(->1) dolichol/ |
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Structure type: oligomer
Aglycon: (->1) dolichol
- Compound ID: 19327
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a-D-Manp-(1-6)-+
|
a-D-Manp-(1-2)-a-D-Manp-(1-3)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1---P---P----/(->1) dolichol/ |
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Structure type: oligomer
Aglycon: (->1) dolichol
- Compound ID: 19328
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a-D-Manp-(1-6)-+
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a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1---P---P----/(->1) dolichol/ |
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Structure type: oligomer
Aglycon: (->1) dolichol
- Compound ID: 19329
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a-D-Manp-(1-3)-a-D-Manp-(1-6)-+
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a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1---P---P----/(->1) dolichol/ |
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Structure type: oligomer
Aglycon: (->1) dolichol
- Compound ID: 19330
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a-D-Manp-(1-2)-a-D-Manp-(1-3)-a-D-Manp-(1-6)-+
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a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1---P---P----/(->1) dolichol/ |
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Structure type: oligomer
Aglycon: (->1) dolichol
- Compound ID: 19331
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a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-+
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a-D-Manp-(1-6)-+ |
| |
a-D-Manp-(1-2)-a-D-Manp-(1-3)-a-D-Manp-(1-6)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1---P---P----/(->1) dolichol/ |
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Structure type: oligomer
Aglycon: (->1) dolichol
- Compound ID: 19332
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a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-+
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a-D-Manp-(1-2)-a-D-Manp-(1-6)-+ |
| |
a-D-Manp-(1-2)-a-D-Manp-(1-3)-a-D-Manp-(1-6)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1---P---P----/(->1) dolichol/ |
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Structure type: oligomer
Aglycon: (->1) dolichol
- Compound ID: 19333
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a-D-Glcp-(1-3)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-+
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a-D-Manp-(1-2)-a-D-Manp-(1-6)-+ |
| |
a-D-Manp-(1-2)-a-D-Manp-(1-3)-a-D-Manp-(1-6)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1---P---P----/(->1) dolichol/ |
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Structure type: oligomer
Aglycon: (->1) dolichol
- Compound ID: 19334
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a-D-Manp-(1-2)-a-D-Manp-(1-6)-+
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a-D-Manp-(1-2)-a-D-Manp-(1-3)-a-D-Manp-(1-6)-+
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a-D-Glcp-(1-3)-a-D-Glcp-(1-3)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1---P---P----/(->1) dolichol/ |
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Structure type: oligomer
Aglycon: (->1) dolichol
- Compound ID: 19335
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a-D-Manp-(1-2)-a-D-Manp-(1-6)-+
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a-D-Manp-(1-2)-a-D-Manp-(1-3)-a-D-Manp-(1-6)-+
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a-D-Glcp-(1-2)-a-D-Glcp-(1-3)-a-D-Glcp-(1-3)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1---P---P----/(->1) dolichol/ |
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Structure type: oligomer
Aglycon: (->1) dolichol
Compound class: N-glycan
- Compound ID: 19336
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a-D-Manp-(1-2)-a-D-Manp-(1-6)-+
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a-D-Manp-(1-2)-a-D-Manp-(1-3)-a-D-Manp-(1-6)-+
|
a-D-Glcp-(1-2)-a-D-Glcp-(1-3)-a-D-Glcp-(1-3)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G72079JG
- Compound ID: 19337
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a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-+
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a-D-Manp-(1-2)-a-D-Manp-(1-6)-+ |
| |
a-D-Manp-(1-2)-a-D-Manp-(1-3)-a-D-Manp-(1-6)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G39578OU
- Compound ID: 19338
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a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-+
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a-D-Manp-(1-6)-+ |
| |
a-D-Manp-(1-2)-a-D-Manp-(1-3)-a-D-Manp-(1-6)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G48148JS
- Compound ID: 19339
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a-D-Manp-(1-2)-a-D-Manp-(1-3)-a-D-Manp-(1-6)-+
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a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-D-GlcpNAc |
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Structure type: oligomer
Reference(s) to other database(s): GTC:G04220HB
- Compound ID: 19308
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a-D-Manp-(1-6)-+
|
a-D-Manp-(1-2)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G62433MP
- Compound ID: 19309
Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G50700QF
- Compound ID: 19310
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a-D-Manp-(1-6)-+
|
a-D-Glcp-(1-3)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G64320QG
- Compound ID: 19311
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b-D-Galf-(1-5)-b-D-Galf-(1-6)-a-D-Manp-(1-6)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G89423WQ
- Compound ID: 19312
|
b-D-Galf-(1-5)-b-D-Galf-(1-5)-b-D-Galf-(1-6)-a-D-Manp-(1-6)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G50111MS
- Compound ID: 19342
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a-D-Manp-(1-3)-a-D-Manp-(1-2)-+ LIP-(1-3)-+
| |
Subst-(1-2)-EtN-(1--P--6)--a-D-Manp-(1-2)-a-D-Manp-(1-6)-a-D-Manp-(1-4)-a-D-GlcN-(1-6)-L-myoIno-(?-1)-Gro-(2-1)-CER
Subst = Aspergillus glycoprotein |
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Structure type: oligomer
Compound class: GPI-anchor
- Compound ID: 19343
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b-D-Xyl-(1-2)-+
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b-D-GlcA-(1-2)-+ |
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b-D-Xyl-(1-2)-+ | |
| | |
-3)-a-D-Manp-(1-3)-a-D-Manp-(1-3)-a-D-Manp-(1-
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b-D-Xyl-(1-4)-+ |
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Structure type: polymer chemical repeating unit
Compound class: glucuronoxylomannan
Reference(s) to other database(s): GTC:G73659MG
- Compound ID: 17754
|
a-D-Manp-(1-3)-a-D-Manp-(1-4)-b-D-Galp-(1-3)-+
|
b-D-Xylp-(1-3)-+ |
| |
b-D-Xylp-(1-2)-+ | |
| | |
b-D-Xylp-(1-3)-a-D-Manp-(1-3)-a-D-Manp-(1-4)-b-D-Galp-(1-3)-+ |
| |
-6)-a-D-Galp-(1-6)-a-D-Galp-(1-6)-a-D-Galp-(1-6)-a-D-Galp-(1- |
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Structure type: polymer chemical repeating unit
Compound class: galactoxylomannan
Reference(s) to other database(s): GTC:G10258DN
- Compound ID: 19304
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a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: mannan, mannoprotein, O-linked glycoprotein
Reference(s) to other database(s): GTC:G95196FC
- Compound ID: 19306
|
a-D-Galf-(1-3)-+
|
a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G63188UG
- Compound ID: 19307
|
a-D-Galf-(1-3)-+
|
a-D-Galf-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G67299DA
- Compound ID: 19302
|
R-Pyr-(2-6:2-4)-b-D-Galp-(1-3)-a-D-Galp-(1-2)-Subst
Subst = α-1,6-mannan backbone |
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Structure type: fragment of a bigger structure
Compound class: mannan, mannoprotein
- Compound ID: 19340
|
a-D-Glcp-(1-3)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)-+
|
a-D-Manp-(1-2)-a-D-Manp-(1-6)-+ |
| |
a-D-Manp-(1-2)-a-D-Manp-(1-3)-a-D-Manp-(1-6)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G24620AI
- Compound ID: 19341
|
EtN-(1--P--2)--+
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EtN-(1--P--6)--+ |
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a-D-Manp-(1-2)-+ | | LIP-(1-3)-+
| | | |
Subst-(1-2)-EtN-(1--P--6)--a-D-Manp-(1-2)-a-D-Manp-(1-6)-a-D-Manp-(1-4)-a-D-GlcN-(1-6)-L-myoIno-(?-1)-Gro-(2-1)-LIP
Subst = Saccharomyces glycoprotein |
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Structure type: oligomer
Compound class: GPI-anchor
- Compound ID: 19313
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a-D-Glcp-(1-4)-a-D-Galp-(1-6)-+
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a-L-Rhap-(1-3)-a-L-Rhap-(1-3)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: O-glycoprotein
Reference(s) to other database(s): GTC:G06047OL
- Compound ID: 19303
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b-D-Manp-(1-2)-b-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1--/(->3) L-Ser/L-Thr (protein)/ |
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Structure type: oligomer
Aglycon: (->3) L-Ser/L-Thr (protein)
Compound class: mannan, mannoprotein, O-linked glycoprotein
Reference(s) to other database(s): GTC:G53868KU